Samuel Edwin "Ed" Weir (March 14, 1903 – May 15, 1991) was an American collegiate and professional football player. He was the first Nebraska Cornhusker football player elected to the College Football Hall of Fame and is known as one of Nebraska's greatest athletes. In 2005 the Omaha World-Herald, as part of a series on the 100 Greatest Athletes of Nebraska, named Weir the 19th best athlete in the state's history.
He went on to play professionally for the Frankford Yellow Jackets of the National Football League. In 1927, he and several teammates took over the coaching job in mid-season and achieved a 6–9–3 record, as Weir earned All-Pro honors. The following year, Weir coached the team to an 11–3–2 record, good for a second-place league finish.