|Systematic (IUPAC) name|
|Mol. mass||339.402 g/mol|
Edivoxetine (INN; LY-2216684) is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly as an antidepressant and as a treatment for attention-deficit hyperactivity disorder (ADHD). As of 2012, it is in phase III clinical trials for major depressive disorder, with initial approval expected by 2013.
In a study published in 2010, edivoxetine failed to prove superiority over placebo, as measured by Hamilton Depression Rating Scale. However, effectiveness could be observed using the Self-Rated Quick Inventory of Depressive Symptomatology.
In a study published in 2011, using the Montgomery-Åsberg Depression Rating Scale and the Sheehan Disability Scale, edivoxetine showed superiority over placebo, with higher response and remission rates.
In December 2013, Eli Lilly announced that the clinical development of edivoxetine will be stopped due to lack of efficacy compared to SSRI alone in three separate clinical trials.
Side effects significantly associated with edivoxetine are headache, nausea, constipation, dry mouth and insomnia.
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