Edivoxetine

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Edivoxetine
Edivoxetine structure.png
Systematic (IUPAC) name
(1R)-2-(5-fluoro-2-methoxyphenyl)-1-[(2S)-morpholin-2-yl]-1-(tetrahydro-2H-pyran-4-yl)ethanol
Clinical data
Legal status
?
Identifiers
CAS number 1194508-25-2
1194374-05-4 (hydrochloride)
ATC code None
PubChem CID 11186829
ChemSpider 9361913
Chemical data
Formula C18H26FNO4 
Mol. mass 339.402 g/mol

Edivoxetine (INN; LY-2216684) is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly as an antidepressant and as a treatment for attention-deficit hyperactivity disorder (ADHD).[1][2] As of 2012, it is in phase III clinical trials for major depressive disorder, with initial approval expected by 2013.[1][3]

Effectiveness[edit]

In a study published in 2010, edivoxetine failed to prove superiority over placebo, as measured by Hamilton Depression Rating Scale. However, effectiveness could be observed using the Self-Rated Quick Inventory of Depressive Symptomatology.[4]

In a study published in 2011, using the Montgomery-Åsberg Depression Rating Scale and the Sheehan Disability Scale, edivoxetine showed superiority over placebo, with higher response and remission rates.[5]

In December 2013, Eli Lilly announced that the clinical development of edivoxetine will be stopped due to lack of efficacy compared to SSRI alone in three separate clinical trials.[6]

Side effects[edit]

Side effects significantly associated with edivoxetine are headache, nausea, constipation, dry mouth and insomnia.[4]

The above mention studies report increases of the cardiac rhythm, and one also increases of diastolic and systolic blood pressures.[4][5]

See also[edit]

References[edit]

  1. ^ a b Jun Yan (March 2012). "Pipeline for new antidepressants flowing slowly". Psychiatric News (American Psychiatric Association) 47 (5): 1b-29. Retrieved 2012-04-27. 
  2. ^ "Statement on a nonproprietary name adopted by the USAN council - Edivoxetine" (Press release). American Medical Association. 2012. Retrieved 2012-04-12. 
  3. ^ Chancellor D (November 2011). "The depression market". Nature Reviews. Drug Discovery 10 (11): 809–10. doi:10.1038/nrd3585. PMID 22037032. 
  4. ^ a b c Dubé S, Dellva MA, Jones M, Kielbasa W, Padich R, Saha A, Rao P (April 2010). "A study of the effects of LY2216684, a selective norepinephrine reuptake inhibitor, in the treatment of major depression". Journal of Psychiatric Research 44 (6): 356–363. doi:10.1016/j.jpsychires.2009.09.013. PMID 19909980. 
  5. ^ a b Pangallo P, Dellva MA, D'Souza DN, Essink B, Russell J, Goldberger C (June 2011). "A randomized, double-blind study comparing LY2216684 and placebo in the treatment of major depressive disorder". Journal of Psychiatric Research 45 (6): 748–755. doi:10.1016/j.jpsychires.2011.03.014. PMID 21511276. 
  6. ^ https://investor.lilly.com/releasedetail.cfm?ReleaseID=811751