Efungumab

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Efungumab ?
Monoclonal antibody
Type Single-chain variable fragment
Source Human
Target fungal Hsp90
Clinical data
Trade names Mycograb
Legal status
?
Routes Intravenous
Pharmacokinetic data
Bioavailability Not applicable (IV only)
Protein binding High
Half-life 1–2 hours
Identifiers
CAS number  YesY
ATC code None
UNII BM86P708HW YesY
Chemical data
Formula ?
Mol. mass Approximately 27.2 kDa
 N (what is this?)  (verify)

Efungumab (trade name Mycograb) is a drug developed by NeuTec Pharma (a subsidiary of Novartis), intended to treat invasive Candida infection in combination with amphotericin B. The European Medicines Agency has twice refused to grant marketing authorization for Mycograb, citing product safety and quality issues.[1]

Chemically, efungumab is a single-chain variable fragment of a human monoclonal antibody.[2] As such, it potentially act similarly to an IgA - inhibiting by binding and blocking.

Its ability to potentiate the effects of the antifungal amphotericin B in culture were later found to be non-specific. [3]

References[edit]

  1. ^ European Medicines Agency (2007). REFUSAL CHMP ASSESSMENT REPORT FOR MYCOGRAB. Procedure No. EMEA/H/C/658 PDF (370 KiB). London: European Medicines Agency. Retrieved on 2007-11-20. Detailed assessment report with comprehensive overview of reasons for refusal of marketing authorization.
  2. ^ World Health Organization (2006). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 95" (PDF). WHO Drug Information 20 (2): 48. 
  3. ^ Nonspecific Effect of Mycograb on Amphotericin B MIC. Antimicrob Agents Chemother v.56(7); Jul 2012 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393390/