El Gordo's often irreverent attitude is balanced by La Flaca's more demure manner. The show combines interviews with actors, musicians, and other celebrities with reports on their comings and goings. The show appears weekdays on the Spanish-language television network Univisión. It is filmed in the network's studios in Miami, Florida.
On December 15, 2006, as a send-off homage to Rebelde, El Gordo y la Flaca opened with the cast dressed in Elite Way school uniforms, with Lili Estefan as Mía Colucci and Raúl De Molina as Giovanni Méndez (complete in dyed orange/red hair), while doing a parody to the show's opening theme, Rebelde. It is notable that the homage was pre-recorded, as Raúl De Molina did not appear on the show on the day when Rebelde was shown for the final time in the United States.