Dorfman moved to New York City in 1959 and found a job as a secretary to the editors at Grove Press, a leading Beat publisher. When she later moved home to Cambridge to pursue her master's degree, she called herself the "Paterson Society" and began arranging readings for many Beat authors who had become friends, maintaining an active correspondence with them as they traveled the world. By 1962, she was teaching fifth grade. A year later, in 1963, Dorfman began working for the Educational Development Corporation whose photographer, George Cope, introduced her to photography in June 1965. She made her first sale two months later, in August 1965, for $25 of a photograph of Charles Olson which was used on the cover of his book The Human Universe. Due to economic limitations, she did not buy her own camera until 1967, when she sent a check for $150 to Philip Whalen who was then in Kyoto, Japan, and he in turn enlisted Gary Snyder, who could speak Japanese, to purchase the camera and mail it to her. In May 1968, she moved into the Flagg Street house which would become the basis of her Housebook.
She is now known for her use of a Polaroid 20 by 24 inch camera (one of only 6 in existence), from which she creates large prints. She has photographed famous writers, poets, and musicians including Bob Dylan and Allen Ginsberg. When Kodak ceased production of Polaroid film in 2008, Dorfman stocked up with a year's supply.