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CAS number 128-20-1
PubChem 31402
ChemSpider 29132
Jmol-3D images Image 1
Molecular formula C21H34O2
Molar mass 318.49 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Pregnanolone (3α-hydroxy-5β-pregnan-20-one or 3α,5β-tetrahydroprogesterone; sometimes abbreviated as 3α,5β-THP), also known as eltanolone (INN), is an endogenous neurosteroid that is synthesized from progesterone.[1] It is a positive allosteric modulator of the GABAA receptor,[1] and is known to have sedative, anxiolytic, and anticonvulsant effects.[1][2]

See also[edit]


  1. ^ a b c Reddy DS (2003). "Pharmacology of endogenous neuroactive steroids". Crit Rev Neurobiol 15 (3-4): 197–234. PMID 15248811. 
  2. ^ Carl P, Høgskilde S, Lang-Jensen T, et al. (October 1994). "Pharmacokinetics and pharmacodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in humans". Acta Anaesthesiol Scand 38 (7): 734–41. PMID 7839787.