Sef Kruse was Vinnie's (Pua Magasiva) womanizing cousin. Sef briefly visited Vinnie in early 2004 before he was hired late in the year as a temporary replacement for Waverley Wilson (Claire Chitham) on reception whilst she was on maternity leave. Sef was often seen accompanying Vinnie on nights out on the town and the two would often try to pull women with disastrous consequences. Sef was last seen in March 2005 when he and Vinnie tried to attract Tania Jeffries (Faye Smythe).
Siobhan O'Leary arrived in mid-2004 as the new nanny for Harry (Callum Campbell-Ross), hired by his father Chris Warner (Michael Galvin). Chris was uneasy about Siobhan's attractiveness and she initially clashed with Harry's mother, Toni (Laura Hill). The two soon became friends and it was not long before Chris and Siobhan began sleeping with each other. However Chris fell in love with Lucy Swinton (Sally Stockwell) and ended up dumping her. The following day Chris discovered a note from Siobhan, stating she had fled Ferndale.
Siobhan Marshall auditioned for the role shortly after graduating and thought the fact that the character shared her name was destiny. She won the role and retained it for several weeks, however she struggled with the recognition on the streets, including an incident where the character was a called a "slut".
Dr. Craig Valentine was the old school friend of Chris Warner (Michael Galvin). He quickly became the head of ED at the hospital and clashed with many due to his fiery and at times, moody, personality. He was portrayed Renato Bartolomei until 2008.
Tina-Anne Trinanty Harrison was the daughter of Nick (Karl Burnett) and Waverley Harrison (Claire Chitham), who was born on the shows 3000th episode. Nick nearly missed her birth but arrived just in time. She was named after Anne Kahu (Emmeline Hawthorne), whilst Judy Brownlee (Donogh Rees) was named as her godmother and Sticky (Ian Hughes) and Eltham Wilson (Kip Chapman) her godfathers. Eltham saved Tina-Anne and her brother Lucas (William Tregidga) from a fire at their home in 2004. She departed alongside her family in March 2005.
Jessica "Jay" Copeland was the estranged daughter of Victor Kahu (Calvin Tuteao). She arrived in mid-2004 with her traveling partner – Maia Jeffries (Anna Jullienne). However it soon became obvious the two were really lovers. Jay was portrayed by Jaime Passier-Armstrong until 2007.
Maia Anne Jeffries was the lesbian girlfriend of Jay Copeland (Jaime Passier-Armstrong). However Maia soon outlasted Jay and became an iconic character on the show, being involved in several high profile stories including the 2009 storyline where Maia confessed to having killed a man. She was portrayed by Anna Jullienne until 2011 and again in May 2012.
Eltham Wilson was the badboy cousin of Waverley Harrison (Claire Chitham). He arrived in August 2004 when Waverley named him as the godmother to her daughter Tina-Anne (Libby Reber). He instantly got on the bad side of Waverley's husband Nick Harrison (Karl Burnett) and Maia Jeffries (Anna Jullienne). He soon fell head over heels in love with Maia but discovered she was a lesbian. Eltham began to work at the bar but Nick was horrified to discover that Eltham was dealing drugs from behind the counter. He also accidentally set the bar alight but was hailed a hero when he rescued Waverley and Nick's children – Lucas (William Tregidga) and Tina-Anne, from the blaze. In November he accepted a job offer in Taranaki and departed after a kiss from Maia.
Malcolm Grieg made a guest appearance over 2 episodes in August 2004. Nick Harrison (Karl Burnett) made the controversial decision to hire the elderly Malcolm as the new CEO after the arrest of Victor Kahu (Calvin Tuteao). However Malcolm proved hugely ill prepared for the job and much of the staff believed he had died 3 years beforehand. Malcolm collapsed at his desk due to respiratory failure and after narrowly surviving, lost his job.
Dr. Andrew Solomon made his first appearance in mid-2004 as the new CEO of the hospital. Andrew's no nonsense attitude caused him to clash with the staff but many saw his lighter side when he began to date Sarah Potts (Amanda Billing) and when his teenage sister Claire (Emily Robins) arrived. A roadblock appeared in the return of Andrew's ex lover Robyn Stokes (Kirstie O'Sullivan) who orchestrated a hit and run to win Andrew back, nearly killing him in the process. She revealed they had an illegitimate son who had died and used Andrew's confused state to sleep with him. Andrew and Sarah wed but Robyn returned and revealed she was pregnant with twins. Sarah and Andrew broke up and he eventually moved to England with Robyn and got a job as a doctor in the countryside. Claire informed Sarah on 21 March 2006 that the babies had been born. In 2007 Chris Warner (Michael Galvin) rang him to inform him of Claire's murder.
Rotondo was openly critical of the character and the show itself, labelling Andrew as the "most boring character in Shortland Street."
Talafao Kruse was the staunch businessman uncle of Vinnie Kruse (Pua Magasiva). He arrived with his daughter Talia (Marlia Rogers) in September and was unimpressed by Vinnie's girlfriend Shannon (Amber Curreen).
Talia Kruse was the cousin of Vinnie (Pua Magasiva) who visited Ferndale alongside her father Talafao Kruse (Joseph Pilitati) and was unimpressed by Vinnie's girlfriend Shannon (Amber Curreen). Talia decided to stay longer in Ferndale and started to date Tama Hudson (David Wikaira-Paul). However the two broke up and Talia returned to Samoa.
Dr. Mark Weston first appeared in an episode set in Fiji. He worked in a clinic there when Chris Warner (Michael Galvin) and Toni McAllister (Laura Hill) visited but it was not long before he landed a job at Shortland Street. He was instantly attracted to Maia Jeffries (Anna Jullienne) and saved her life when his psychopathic friend Hugo Carmont (Fraser Brown) tried to kill her in exchange for Mark's romance. Mark began to date Maia's sister Tania (Faye Smythe) but he cheated on her with school girl Claire Solomon (Emily Robins) which ended the relationship. Mark had a near romance with Toni but reconciled with Tania but when he discovered an addiction to sex when online dating, Tania forced him to seek help. The two married in 2007 but Mark's love for Maia took over and he donated sperm to her behind Tania's back. Mark also landed himself as a lead suspect in several murders that took place. The stress got to him and he cheated on Tania with Meg Harris (Emily Mowbray) at his birthday party before he confessed the truth about he and Maia's child to the Jeffries family. Isolated and wifeless, Mark departed Ferndale for Australia. With the marriage annulled it was later revealed Mark had remarried and had a child.
Morgan Potts was the father of Sarah Potts (Amanda Billing). He and his wife Pam (Teresa Woodham) had raised Sarah's illegitimate son Daniel (Jarred Blakiston) as their own and arrived in 2004 to let him visit Sarah. The truth soon came out however and Daniel went to live with Sarah. In 2005 Morgan and Pam attended Sarah's wedding to Andrew Solomon (Paolo Rotondo). The couple returned in 2007 when they met Sarah's new fiance TK Samuels (Benjamin Mitchell). The couple left at odds with TK when Morgan continuously forgot his name. In 2011 Sarah announced that her parents were living in the Bay of Islands and would not be visiting for the birth of her daughter. In 2012 the couple talked to Daniel (Ido Drent) and Sarah on Skype.
Daniel Potts was the illegitimate child of Sarah Potts (Amanda Billing). He was raised as her brother but when he discovered the truth, came to resent Sarah. He was portrayed by Jarred Blakiston) in recurring stints until 2005 and again in 2007. The role was recast in 2009 with Ido Drent taking on the character in a regular role.
Pam Potts was the controlling mother of Sarah Potts (Amanda Billing). She and her husband Morgan (Michael Morrissey) dropped Sarah's son Daniel (Jarred Blakiston) to Sarah's. Pam was disgusted when Sarah planned to reveal she was his mother and not his sister. Pam tried to keep Daniel but he insisted on being taken in by Sarah. In 2005 Pam returned with Morgan for Sarah's wedding to Andrew (Paolo Rotondo) and expressed joy at the coupling. However in 2007 when Pam met Sarah's new fiance TK Samuels (Benjamin Mitchell), she was constantly at odds at him when Sarah rebuffed her confrontational behaviour. In 2011 Sarah announced that her parents were living in the Bay of Islands and would not be visiting for the birth of her daughter. Pam suggested the name of Matilda which was eventually chosen. In 2012 the couple talked to Daniel (Ido Drent) and Sarah on Skype.
Yvonne Jeffries (née Gregory) was the interfering mother of Maia Jeffries (Anna Jullienne). The character arrived in a guest role in 2004, before becoming the hospital receptionist in 2005. She participated in numerous high profile storylines, the most prominent of which was her relationship with daughter Tania's (Faye Smythe) ex-boyfriend – Ben Goodall (Shaun Edwards-Brown). She was portrayed by Alison Quigan until 2011 and again in May 2012.
Ian Jeffries was the husband of Yvonne (Alison Quigan). The two arrived in November 2004 and an increasingly frail Ian was diagnosed with Motor Neurone Disease. The couple returned the following year and Ian was re-diagnosed with Kennedy's disease. Ian was a lot more accepting of daughter Maia (Anna Jullienne), when she revealed she was gay than Yvonne and he grew to appreciate Maia's girlfriend Jay (Jaime Prassier-Armstrong). Ian was sent away to rehab but when he returned Yvonne suspected he was cheating. After Maia's wedding he confessed his love and that he would never cheat and the two reconciled. Days later Yvonne found Ian's body off the side of a cliff, he had killed himself due to his deteriorating illness.
Claire Simone Solomon made her first appearance on Christmas Day 2004. Claire was the troublesome teenage sister of hospital CEO, Andrew Solomon (Paolo Rotondo) and quickly became a fan favourite. Claire arrived unexpectedly back into Andrew's life in late 2004 after spending 8 years in England. Claire scandalously briefly dated older man, Maestro (Gregory Paintin) before over dosing on stolen morphine. She began to date Jake Valentine (Calum Gittins) before accidentally running someone over in her car lead to her controlling her bad-girl ways. However Claire left Jake for an affair with much older doctor, Mark Weston (Tim Foley) and much of the hospital staff rallied against her. Claire found a new lease for life in dating religious fanatic, Baxter Cormack (Tom Hern). The two became engaged but he ended up dumping her for religion. Claire scandalously had an affair with flat mate Kieran Mitchell (Adam Rickitt) whilst he was dating Libby Jeffries (Fleur Saville) before she had a brief fling with Joey Henderson (Johnny Barker). In July 2007, Claire's naked body was found in a hospital dumpster and it was clear she had been murdered. In December it was revealed she, alongside 4 other women, had been murdered by Joey.