Elvucitabine

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Elvucitabine
Elvucitabine.png
Systematic (IUPAC) name
4-amino-5-fluoro-1-[(2S,5R)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2-one
Clinical data
Legal status
?
Identifiers
CAS number 181785-84-2 YesY
ATC code None
PubChem CID 469717
UNII M09BUF90C0 YesY
ChEMBL CHEMBL38700 N
NIAID ChemDB 060327
Chemical data
Formula C9H10FN3O3 
Molecular mass 227.19 g/mol
 N (what is this?)  (verify)

Elvucitabine is an experimental nucleoside reverse transcriptase inhibitor (NRTI), developed by Achillion Pharmaceuticals, Inc. for the treatment of HIV.

Elvucitabine is an investigational drug that is being studied for the treatment of HIV infection.

Elvucitabine belongs to a class (group) of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs).[1] NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

Elvucitabine is similar in chemical structure to the FDA-approved NRTIs Lamivudine (brand name: Epivir) and Emtricitabine (brand name: Emtriva). However, in vitro studies have suggested that elvucitabine may work on certain HIV strains against which other NRTIs, such as lamivudine and emtricitabine, no longer work. (In vitro studies are studies done in test tubes or other laboratory equipment and not on animals or humans.)

Studies have also suggested that elvucitabine may be effective against hepatitis B virus (HBV)[2]

Currently, it is in Phase II clinical trials.[3]

References[edit]

  1. ^ [1]
  2. ^ [2]
  3. ^ "Elvucitabine". AIDSmeds.com. November 5, 2007. Retrieved March 21, 2008.