Embryonal rhabdomyosarcoma

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Embryonal rhabdomyosarcoma
Classification and external resources
OMIM 268210 180295
DiseasesDB 1557

Embryonal rhabdomyosarcoma (ERMS) is a rare histological form of cancer of connective tissue wherein the mesenchymally-derived malignant cells resemble the primitive developing skeletal muscle of the embryo. It is the most common soft tissue sarcoma occurring in children.[1]

Classification[edit]

ERMS is the more common of two major subtypes of rhabdomyosarcoma, the other being alveolar rhabdomyosarcoma.

It has been informally classified as a "small round blue cell tumor"[1] because of the characteristic microscopic appearance of its cells after histological staining with hematoxylin and eosin.

Prognosis and survival[edit]

The prognosis for rhabdomyosarcoma has improved greatly in recent decades, with over 70% of patients surviving for five years after diagnosis.[2]

References[edit]

  1. ^ a b Masola V, Maran C, Tassone E, Zin A, Rosolen A, Onisto M (2009). "Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion". BMC Cancer 9: 304. doi:10.1186/1471-2407-9-304. PMC 2743710. PMID 19715595. 
  2. ^ Breitfeld PP, Meyer WH (August 2005). "Rhabdomyosarcoma: new windows of opportunity". Oncologist 10 (7): 518–27. doi:10.1634/theoncologist.10-7-518. PMID 16079319.