Emil Kraepelin in his later years
15 February 1856|
|Died||7 October 1926
|Institutions||University of Dorpat,
University of Heidelberg,
University of Munich
|Alma mater||Leipzig University,
University of Würzburg,
University of Munich
|Thesis||The Place of Psychology in Psychiatry|
|Known for||Classification of mental disorders,
Bernhard von Gudden,
Karl Ludwig Kahlbaum
|Influenced||Diagnostic and Statistical Manual of Mental Disorders,
International Statistical Classification of Diseases and Related Health Problems
Emil Kraepelin (15 February 1856 – 7 October 1926) was a German psychiatrist. H.J. Eysenck's Encyclopedia of Psychology identifies him as the founder of modern scientific psychiatry, as well as of psychopharmacology and psychiatric genetics. Kraepelin believed the chief origin of psychiatric disease to be biological and genetic malfunction. His theories dominated psychiatry at the start of the twentieth century and, despite the later psychodynamic influence of Sigmund Freud and his disciples, enjoyed a revival at century's end.
Family and early life 
Kraepelin, the son of a civil servant, was born in 1856 in Neustrelitz, in the Duchy of Mecklenburg-Strelitz in Germany. He was first introduced to biology by his brother Karl, 10 years older and, later, the director of the Zoological Museum of Hamburg.
Kraepelin began his medical studies at 18, in Leipzig and Würzburg, Germany. At Leipzig, he studied neuropathology under Paul Flechsig and experimental psychology with Wilhelm Wundt. Kraepelin would be a disciple of Wundt and had a lifelong interest in experimental psychology based on his theories. While there, Kraepelin wrote a prize-winning essay, "The Influence of Acute Illness in the Causation of Mental Disorders." He received his medical degree (M.D.) in 1878. In 1879, he went to work with Bernhard von Gudden at the University of Munich, where he completed his thesis, "The Place of Psychology in Psychiatry". Returning to the University of Leipzig in 1882, he worked in Wilhelm Heinrich Erb's neurology clinic and in Wundt's psychopharmacology laboratory.
Kraepelin's major work, Compendium der Psychiatrie, was first published in 1883. In it, he argued that psychiatry was a branch of medical science and should be investigated by observation and experimentation like the other natural sciences. He called for research into the physical causes of mental illness, and started to establish the foundations of the modern classification system for mental disorders. Kraepelin proposed that by studying case histories and identifying specific disorders, the progression of mental illness could be predicted, after taking into account individual differences in personality and patient age at the onset of disease.
In 1884 he became senior physician in the Prussian provincial town of Leubus and the following year he was appointed director of the Treatment and Nursing Institute in Dresden. In 1886, at the age of 30, Kraepelin was named professor of psychiatry at the University of Dorpat (today the University of Tartu) in what is today Estonia (see Burgmair et al., Vol IV). Four years later, he became department head at the University of Heidelberg, where he remained until 1903. Whilst at Dorpat he became the director of the eighty-bed University Clinic. There he began to study and record many clinical histories in detail and "was led to consider the importance of the course of the illness with regard to the classification of mental disorders."
In 1912 at the request of the German Society of Psychiatry, he began plans to establish a centre for research. Following a large donation from the Jewish German American banker James Loeb who had at one time been a patient, and promises of support from 'patrons of science', the German Institute for Psychiatric Research was founded in 1917 in Munich. Initially housed in existing hospital buildings, it was maintained by further donations from Loeb and his relatives. In 1924 it came under the auspices of the Kaiser Wilhelm Society for the Advancement of Science. The German American Rockefeller family's Rockefeller Foundation made a large donation enabling the development of a new dedicated building for the institute, along Kraepelin's guidelines, which was officially opened in 1928.
Kraepelin spoke out against the barbarous treatment that was prevalent in the psychiatric asylums of the time, and crusaded against alcohol, capital punishment and the imprisonment rather than treatment of the insane. He rejected psychoanalytical theories that posited innate or early sexuality as the cause of mental illness, and rejected philosophical speculation as unscientific. He focused on collecting clinical data, and was particularly interested in neuropathology (e.g. diseased tissue).
Kraepelin retired from teaching at the age of 66, spending his remaining years establishing the Institute. The final edition of his Textbook of Psychiatry was published in 1927, shortly after his death. It comprised four volumes and was ten times larger than the first edition of 1883.
Theories and classification schemes 
Kraepelin announced that he had found a new way of looking at mental illness. He referred to the traditional view as "symptomatic" and to his view as "clinical". This turned out to be his paradigm-setting synthesis of the hundreds of mental disorders classified by the 19th century, grouping diseases together based on classification of syndromes — common patterns of symptoms — rather than by simple similarity of major symptoms in the manner of his predecessors. In fact, it was precisely because of the demonstrated inadequacy of such methods that Kraepelin developed his new diagnostic system.
Psychosis and mood 
Kraepelin is specifically credited with the classification of what was previously considered to be a unitary concept of psychosis, into two distinct forms (known as the Kraepelinian dichotomy):
- manic depression (now seen as comprising a range of mood disorders such as recurrent major depression and bipolar disorder), and
- dementia praecox.
Drawing on his long-term research, and using the criteria of course, outcome and prognosis, he developed the concept of dementia praecox, which he defined as the "sub-acute development of a peculiar simple condition of mental weakness occurring at a youthful age." When he first introduced this concept as a diagnostic entity in the fourth German edition of his Lehrbuch der Psychiatrie in 1893, it was placed among the degenerative disorders alongside, but separate from, catatonia and dementia paranoides. At that time, the concept corresponded by and large with Ewald Hecker's hebephrenia. In the sixth edition of the Lehrbuch in 1899 all three of these clinical types are treated as different expressions of one disease, dementia praecox.
One of the cardinal principles of his method was the recognition that any given symptom may appear in virtually any one of these disorders; e.g., there is almost no single symptom occurring in dementia praecox which cannot sometimes be found in manic-depression. What distinguishes each disease symptomatically (as opposed to the underlying pathology) is not any particular (pathognomonic) symptom or symptoms, but a specific pattern of symptoms. In the absence of a direct physiological or genetic test or marker for each disease, it is only possible to distinguish them by their specific pattern of symptoms. Thus, Kraepelin's system is a method for pattern recognition, not grouping by common symptoms.
Kraepelin also demonstrated specific patterns in the genetics of these disorders and specific and characteristic patterns in their course and outcome. Generally speaking, there tend to be more schizophrenics among the relatives of schizophrenic patients than in the general population, while manic-depression is more frequent in the relatives of manic-depressives. Though, of course, this does not demonstrate genetic linkage, as this might be a socio-environmental factor as well.
He also reported a pattern to the course and outcome of these conditions. Kraepelin believed that schizophrenia had a deteriorating course in which mental function continuously (although perhaps erratically) declines, while manic-depressive patients experienced a course of illness which was intermittent, where patients were relatively symptom-free during the intervals which separate acute episodes. This led Kraepelin to name what we now know as schizophrenia, dementia praecox (the dementia part signifying the irreversible mental decline). It later became clear that dementia praecox did not necessarily lead to mental decline and was thus renamed schizophrenia by Eugen Bleuler to correct Kraepelin's misnomer.
In addition, as Kraepelin accepted in 1920, "It is becoming increasingly obvious that we cannot satisfactorily distinguish these two diseases." However, he maintained that "On the one hand we find those patients with irreversible dementia and severe cortical lesions. On the other are those patients whose personality remains intact.". Nevertheless, overlap between the diagnoses and neurological abnormalities (when found) have continued, and in fact a diagnostic category of schizoaffective disorder would be brought in to cover the intermediate cases.
Kraepelin devoted very few pages to his speculations about the etiology of his two major insanities, dementia praecox and manic-depressive insanity. However, from 1896 to his death in 1926 he held to the speculation that these insanities (particularly dementia praecox) would one day probably be found to be caused by a gradual systemic or "whole body" disease process, probably metabolic, which affected many of the organs and nerves in the body but affected the brain in a final, decisive cascade.
Psychopathic personalities 
In the first through sixth edition of Kraepelin's influential psychiatry textbook, there was a section on moral insanity, which meant then a disorder of the emotions or moral sense without apparent delusions or hallucinations, and which Kraepelin defined as 'lack or weakness of those sentiments which counter the ruthless satisfaction of egotism'. He attributed this mainly to degeneration. This has been described as a psychiatric redefinition of Cesare Lombroso's theories of the 'born criminal', conceptualised as a 'moral defect', though Kraepelin stressed it was not yet possible to recognise them by physical characteristics.
In fact from 1904 Kraepelin changed the section heading to 'The born criminal', moving it from under 'Congenital feeblemindedness' to a new chapter on 'Psychopathic personalities'. They were treated under a theory of degeneration. Four types were distinguished: born criminals (inborn delinquents), pathological liars, querulous persons, and Triebmenschen (persons driven by a basic compulsion, including vagabonds, spendthrifts, and dipsomaniacs). The concept of 'psychopathic inferiorities' had been recently popularised in Germany by Julius Ludwig August Koch, who proposed congenital and acquired types. Kraepelin had no evidence or explanation suggesting a congenital cause, and his assumption therefore appears to have been simple 'biologism'. Others, such as Gustav Aschaffenburg, argued for a varying combination of causes. Kraepelin's assumption of a moral defect rather than a positive drive towards crime has also been questioned, as it implies that the moral sense is somehow inborn and unvarying, yet it was known to vary by time and place, and Kraepelin never considered that the moral sense might just be different. Kurt Schneider criticized Kraepelin's nosology for appearing to be a list of behaviors that he considered undesirable, rather than medical conditions, though Schneider's alternative version has also been criticised on the same basis. Nevertheless, many essentials of these diagnostic systems were introduced into the diagnostic systems, and remarkable similarities remain in the DSM-IV and ICD-10. The issues would today mainly be considered under the category of personality disorders, or in terms of Kraepelin's focus on psychopathy.
Kraepelin had referred to psychopathic conditions (or 'states') in his 1896 edition, including compulsive insanity, impulsive insanity, homosexuality, and mood disturbances. From 1904, however, he instead termed those 'original disease conditions', and introduced the new alternative category of psychopathic personalities. In the eight edition from 1909 that category would include, in addition to a separate 'dissocial' type, the excitable, the unstable, the Triebmenschen driven persons, eccentrics, the liars and swindlers, and the quarrelsome. It has been described as remarkable that Kraepelin now considered mood disturbances to be not part of the same category, but only attenuated (more mild) phases of manic depressive illness; this corresponds to current classification schemes.
Alzheimer's disease 
Kraepelin postulated that there is a specific brain or other biological pathology underlying each of the major psychiatric disorders. As a colleague of Alois Alzheimer, and co-discoverer of Alzheimer's disease, it was his laboratory which discovered its pathologic basis. Kraepelin was confident that it would someday be possible to identify the pathologic basis of each of the major psychiatric disorders.
Degeneration of the race 
Upon moving to become Professor of Clinical Psychiatry at the University of Munich in 1903, Kraepelin increasingly wrote on social policy issues. He was a strong and influential proponent of eugenics and racial hygiene. His publications included a focus on alcoholism, crime, degeneration and hysteria. He was concerned to preserve and enhance the German people, the Volk, in the sense of nation or race. He appears to have held Lamarckian concepts of evolution, such that cultural deterioration could be inherited. He was a strong ally and promoter of the work of fellow psychiatrist Ernst Rudin to clarify the mechanisms of genetic inheritance as to make a so-called 'empirical genetic prognosis'.
Martin Brune has pointed out that Kraepelin and Rudin also appear to have been ardent advocates of a self-domestication theory, a version of social darwinism which held that modern culture was not allowing people to be weeded out, resulting in more mental disorder and deterioration of the gene pool. Kraepelin saw a number of 'symptoms' of this, such as "weakening of viability and resistance, decreasing fertility, proletarianisation, and moral damage due to 'penning up people' [original 'Zusammenpferchung']". He also wrote that "the number of idiots, epileptics, psychopaths, criminals, prostitutes, and tramps who descend from alcoholic and syphilitic parents, and who transfer their inferiority to their offspring, is incalculable." He felt that "the well-known example of the Jews, with their strong disposition towards nervous and mental disorders, teaches us that their extraordinarily advanced domestication may eventually imprint clear marks on the race". Brune states that Kraepelin's nosological system was 'to a great deal, built on the degeneration paradigm'.
Kraepelin's great contribution in classifying schizophrenia and manic-depression remains relatively unknown to the general public, and his work, which had neither the literary quality nor paradigmatic power of Freud's, is little read outside scholarly circles. Kraepelin's contributions were to a large extent marginalized throughout a good part of the twentieth century, during the success of Freudian etiological theories. However, his views now dominate psychiatric research and academic psychiatry, and today the published literature in the field of psychiatry is overwhelmingly biological in its orientation. His fundamental theories on the etiology and diagnosis of psychiatric disorders form the basis of all major diagnostic systems in use today, especially the American Psychiatric Association's DSM-IV and the World Health Organization's ICD system. In that sense, not only is Kraepelin's significance historical, but contemporary psychiatric research is also heavily influenced by his work.
Kraepelin in general has been described as a 'scientific manager' and political operator, who developed a large-scale, clinically oriented, epidemiological research programme. He took in clinical information from a wide range of sources and networks. Despite proclaiming high clinical standards for himself to gather information 'by means of expert analysis of individual cases', he would also draw on the reported observations of officials not trained in psychiatry. However, the various editions of his textbooks do not contain detailed case histories of individuals, but instead mosaic-like compilations of typical statements and behaviors from patients with a specific diagnosis. Kraepelin wrote in a knapp und klar (concise and clear) style that made his books useful tools for physicians. Abridged and clumsy English translations of the sixth and seventh editons of his textbook in 1902 and 1907 (respectively) by Allan Ross Diefendorf (1871-1943), an assistant physician at the Connecticut Hospital for the Insane at Middletown, inadequately conveyed the literary quality of his writings that made them so valuable to practitioners. He has been described as a bourgeois or reactionary citizen.
In the Heidelberg and early Munich years he edited Psychologische Arbeiten, a journal on experimental psychology. One of his own famous contributions to this journal also appeared in the form of a monograph (105 p.) entitled Über Sprachstörungen im Traume (on language disturbances in dreams). Kraepelin, on the basis on the dream-psychosis analogy, studied for more than 20 years language disorder in dreams in order to study indirectly schizophasia. The dreams Kraepelin collected are mainly his own. They lack extensive comment by the dreamer. In order to study them the full range of biographical knowledge available today on Kraepelin is necessary (see e.g. Burgmair et al., I-VII).
- On Kraepelin's early life and family, see Burgmair et al., vol. I. as well as his Memoirs (Berlin: Springer, 1987).
- Kraepelin, Emil (1856-1926) by Margaret Alic, 2001
- Yuhas, Daisy. "Throughout History, Defining Schizophrenia Has Remained a Challenge (Timeline)". Scientific American Mind (March 2013). Retrieved 2 March 2013.
- Berrios, GE., Luque, R., Villagran, JM. (2003). Schizophrenia: a conceptual history. International Journal of Psychology and Psychological Therapy 3: No 2: 111–140
- Noll, Richard. "Whole Body Madness". Psychiatric Times. Retrieved 26 September 2012.
- Richard F. Wetzell (2000) Inventing the criminal: a history of German criminology, 1880-1945 from pg 59 & from 146, misc
- Henning Sass & Alan Felthous (2008) Chapter 1: History and Conceptual Development of Psychopathic Disorders in International Handbook on Psychopathic Disorders and the Law. Edited by Alan Felthous, Henning Sass
- Engstrom, E. J. (1 September 2007). "`On the Question of Degeneration' by Emil Kraepelin (1908)1". History of Psychiatry 18 (3): 389–398. doi:10.1177/0957154X07079689.
- Brüne, Martin (1 January 2007). "On human self-domestication, psychiatry, and eugenics". Philosophy, Ethics, and Humanities in Medicine 2 (1): 21. doi:10.1186/1747-5341-2-21.
- On the reception of Kraepelin's work in the 20th century, see Eric J. Engstrom and Matthias Weber. Making Kraepelin History: A Great Instauration? In: History of Psychiatry 18.3 (2007): 267-273.
- Noll, Richard. "The Bed Makes Gestures". Psychiatric times. Retrieved February 2013.
- Shepherd, M. (1 August 1995). "Two faces of Emil Kraepelin". The British Journal of Psychiatry 167 (2): 174–183. doi:10.1192/bjp.167.2.174. PMID 7582666.
- Über Sprachstörungen im Traume (1906)
- Burgmair, Wolfgang & Eric J. Engstrom & Matthias Weber, et al., eds. Emil Kraepelin. 7 vols. Munich: belleville, 2000-2008.
- Vol. VII: Kraepelin in Munich, Teil II: 1914-1920 (2009), ISBN 978-3-933510-96-9
- Vol. VI: Kraepelin in Munich, Teil I: 1903-1914 (2006), ISBN 3-933510-95-3
- Vol. V: Kraepelin in Heidelberg, 1891-1903 (2005), ISBN 3-933510-94-5
- Vol. IV: Kraepelin in Dorpat, 1886-1891 (2003), ISBN 3-933510-93-7
- Vol. III: Briefe I, 1868-1886 (2002), ISBN 3-933510-92-9
- Vol. II: Kriminologische und forensische Schriften: Werke und Briefe (2001), ISBN 3-933510-91-0
- Vol. I: Persönliches, Selbstzeugnisse (2000), ISBN 3-933510-90-2
- Kraepelin, E. (1906). Über Sprachstörungen im Traume. Leizpig: Engelmann.
- Kraepelin, E. (1987). Memoirs. '''Berlin, Heidelberg, New York: Springer-Verlag'''. ISBN 978-3-642-71926-4
- Noll, Richard (2011) American Madness: The Rise and Fall of Dementia Praecox. Cambridge and London: Harvard University Press.
- Briole, G. (2012). "Emil Kraepelin: The Fragility of a Colossal Oeuvre". Hurly-Burly 8: 125-147.
- Extensive bibliography of English translations of Kraepelin's works
- Extensive bibliography of works by and about Kraepelin's including those in the original German
- International Kraepelin Society contact
- Kraepelin's monograph Über Sprachstörungen im Traume
- Pulse-Project Audio Lecture: Dr. Octavian Buda on "From Psychiatry in Dorpat to Eugenics in Munich: The late works of Emil Kraepelin."
For biographies of Kraepelin see:
- uni-leipzig.de/~psy/eng/kraep-e.html and
For English translations of Kraepelin's work see:
- On Uprootedness (1921)
- Emil Kraepelin's Clinical Self-Assessment (1920)
- Psychiatric Observations on Contemporary Issues (1919)
- On the Question of Degeneration (1908)
- The Directions of Psychiatric Research (1887)