Empty sella syndrome

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Empty sella syndrome
Classification and external resources
Empty sella MRI.png
ICD-9 253.8
DiseasesDB 31523
MedlinePlus 000349
MeSH D004652
Empty sella in MRI (T2w sagittal)

Empty sella syndrome (abbreviated ESS) is a disorder that involves the sella turcica "Turkish Saddle", a bony structure at the base of the brain that surrounds and protects the pituitary gland. ESS is a condition that is often discovered during tests for pituitary disorders, when radiological imaging of the pituitary gland reveals a sella turcica that appears to be empty ("partially empty sella"). The pituitary gland shrinks or becomes flattened. [1]


There are two types of ESS: primary and secondary.

  • Primary ESS happens when a small anatomical defect above the pituitary gland increases pressure in the sella turcica and causes the gland to flatten out along the interior walls of the sella turcica cavity. Primary ESS is associated with obesity and high blood pressure in women. The disorder can be a sign of idiopathic intracranial hypertension.
  • Secondary ESS is the result of the pituitary gland regressing within the cavity after an injury, surgery, or radiation therapy. Individuals with secondary ESS due to destruction of the pituitary gland have symptoms that reflect the loss of pituitary functions, such as the ceasing of menstrual periods, infertility, fatigue, and intolerance to stress and infection.

Associated conditions and diagnosis[edit]

ESS may be associated with early onset of puberty, growth hormone deficiency, pituitary tumors, or pituitary gland dysfunction.

MRI scans are useful in evaluating ESS and differentiating it from other disorders that produce an enlarged sella.


Unless the syndrome results in other medical problems, treatment for endocrine dysfunction associated with pituitary malfunction is symptomatic and supportive. In some cases, surgery may be needed.


ESS is not a life-threatening illness.


External links[edit]