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In chemical thermodynamics, an endergonic reaction (also called a nonspontaneous reaction or an unfavorable reaction) is a chemical reaction in which the standard change in free energy is positive, and energy is absorbed. In layman's terms the total amount of energy is a loss (it takes more energy to start the reaction than what you get out of it) so the total energy is a negative net result. For an overall gain in the net result see Exergonic Reaction.
Under constant temperature and constant pressure conditions, this means that the change in the standard Gibbs free energy would be positive
The equilibrium constant for the reaction is related to ΔG° by the relation:
so that starting from molar stoichiometric quantities such a reaction would move backwards toward equilibrium, not forwards.
Nevertheless, endergonic reactions are quite common in nature, especially in biochemistry and physiology. Examples of endergonic reactions in cells include protein synthesis, and the Na+/K+ pump which drives nerve conduction and muscle contraction.
Making Endergonic reactions happen
Endergonic reactions can be achieved if they are either pulled or pushed by an exergonic (stability increasing, negative change in Free Energy) process.
Reagents can be pulled through an endergonic reaction, if the reaction products are cleared rapidly by a subsequent exergonic reaction. The concentration of the products of the endergonic reaction thus always remains low, so the reaction can proceed.
A classic example of this might be the first stage of a reaction which proceeds via a transition state. The process of getting to the top of the activation energy barrier to the transition state is endergonic. However, the reaction can proceed because having reached the transition state, it rapidly evolves via an exergonic process to the more stable final products.
Endergonic reactions can be pushed by coupling them to another reaction which is strongly exergonic, through a shared intermediate.
This is often how biological reactions proceed. For example, on its own the reaction
may be too endergonic to occur. However it may be possible to make it occur by coupling it to a strongly exergonic reaction – such as, very often, the decomposition of ATP into ADP and inorganic phosphate ions, ATP → ADP + Pi, so that
This kind of reaction, with the ATP decomposition supplying the free energy needed to make an endergonic reaction occur, is so common in cell biochemistry that ATP is often called the "universal energy currency" of all living organisms.