|Organs derived from endoderm.|
|Gives rise to||splanchnopleure|
Endoderm is one of the three primary germ cell layers in the very early embryo. The other two layers are the ectoderm (outside layer) and mesoderm (middle layer), with the endoderm as the innermost layer. Cells migrating inward along the archenteron form the inner layer of the gastrula, which develops into the endoderm.
The endoderm consists at first of flattened cells, which subsequently become columnar. It forms the epithelial lining of multiple systems.
The following chart shows the products produced by the endoderm. The embryonic endoderm develops into the interior linings of two tubes in the body, the digestive and respiratory tube.
|General||Gastrointestinal tract.||the entire alimentary canal except part of the mouth, pharynx and the terminal part of the rectum (which are lined by involutions of the ectoderm), the lining cells of all the glands which open into the digestive tube, including those of the liver and pancreas|
|General||Respiratory tract||the trachea, bronchi, and alveoli of the lungs|
|General||Endocrine glands and organs||the lining of the follicles of the thyroid gland and thymus|
|Auditory system||the epithelium of the auditory tube and tympanic cavity|
|Urinary system||the urinary bladder and part of the urethra|
Liver and pancreas cells are believed to derive from a common precursor.
In humans,the endoderm can differentiate into distinguishable organs after 5 weeks of embryonic development.
Signaling pathway to inducing endoderm
- Langman's Medical Embryology, 11th edition. 2010.
- Gilbert, SF. "Edoderm". Sinauer Associates. Retrieved 14 March 2013.
- The General category denotes that all or most of the animals containing this layer produce the adjacent product.
- Zaret KS (October 2001). "Hepatocyte differentiation: from the endoderm and beyond". Curr. Opin. Genet. Dev. 11 (5): 568–74. doi:10.1016/S0959-437X(00)00234-3. PMID 11532400.
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