Endogenous Depression is an atypical sub-class of the mood disorder, major depressive disorder (clinical depression). Endogenous depression includes patients with treatment-resistant, non-psychotic, major depressive disorder, characterized by abnormal behavior of the endogenous opioid system but not the monoaminergic system.
Endogenous depression was initially considered valuable as a means of diagnostic differentiation with reactive depression. While the latter's onset could be attributed to adverse life events and treated with talk therapy, the former would indicate treatment with antidepressants. Indeed, this view of endogenous depression is at the root of the popular view that mood disorders are a reflection of a 'chemical imbalance' in the brain. More recent research has shown that the probability of an endogenous depression patient experiencing an adverse life event prior to a depressive episode is roughly the same as for a reactive depression patient and the efficacy of antidepressant therapy bears no statistical correlation with the patient's diagnostic classification along this axis. Recent studies have shown that this type of depression appears to be linked with adverse sexual behaviours. 
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- Kramer, T (2002). "Endogenous Versus Exogenous: Still Not the Issue". Medscape Psychopharmacology Today. 7 1.
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- Classification of depression on NetDoctor
- Endogenous Depression Information
- Endogenous Depression Help Resources
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