From Wikipedia, the free encyclopedia
Jump to: navigation, search
Endomorphin 1.svg
Endomorphin 2.svg
CAS number 189388-22-5 (Endomorphin-1) N, 141801-26-5 (Endomorphin-2) YesY
PubChem 5311080 (Endomorphin-1), 5311081 (Endomorphin-2)
ChemSpider 4470614 (Endomorphin-1) N, 4470615 (Endomorphin-2)
Jmol-3D images Image 1
Image 2
Molecular formula C34H38N6O5 (Endmorphin-1)
C32H37N5O5 (Endomorphin-2)
Molar mass 610.703 g/mol (Endomorphin-1)
571.667 g/mol (Endomorphin-2)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Endomorphins are a group of endogenous opioid peptides consisting of endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2). They are tetrapeptides with the highest known affinity and specificity for the μ-opioid receptor. Endomorphin-1 is found in the nucleus of the solitary tract, the periventricular hypothalamus, and the dorsomedial hypothalamus, where it is found within histaminergic neurons and may regulate sedative and arousal behaviors.[1] It is assumed that endomorphins are the cleavage products of a larger precursor, but this polypeptide or protein has not yet been identified.

See also[edit]


  1. ^ Greco, MA; Fuller, PM; Jhou, TC; Martin-Schild, S; Zadina, JE; Hu, Z; Shiromani, P; Lu, J (2008). "Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus". Brain Research 1245: 96–107. doi:10.1016/j.brainres.2008.09.043. PMC 2753822. PMID 18840417.