Endothelin converting enzyme 1

Endothelin converting enzyme 1
Human ECE-1 complexed with phosphoramidon. PDB 3dwb
Available structures PDB PDBe, RCSB
Identifiers
Symbols	ECE1; ECE
External IDs	OMIM: 600423 MGI: 1101357 HomoloGene: 1068 GeneCards: ECE1 Gene
EC number	3.4.24.71
Gene Ontology Molecular function • endopeptidase activity • metalloendopeptidase activity • peptidase activity • peptide hormone binding • protein homodimerization activity • metal ion binding Cellular component • membrane fraction • endosome • early endosome • plasma membrane • plasma membrane • external side of plasma membrane • integral to membrane • intrinsic to endosome membrane • vesicle • Weibel-Palade body • perinuclear region of cytoplasm Biological process • response to hypoxia • positive regulation of receptor recycling • regulation of systemic arterial blood pressure by endothelin • apoptosis • heart development • substance P catabolic process • bradykinin catabolic process • calcitonin catabolic process • peptide hormone processing • regulation of vasoconstriction • endothelin maturation • hormone catabolic process • embryonic digit morphogenesis • ear development • positive regulation of G-protein coupled receptor protein signaling pathway • protein maturation by peptide bond cleavage • pharyngeal system development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1889	230857
Ensembl	ENSG00000117298	ENSMUSG00000057530
UniProt	P42892	Q3TUZ3
RefSeq (mRNA)	NM_001113347.1	NM_199307.2
RefSeq (protein)	NP_001106818.1	NP_955011.1
Location (UCSC)	Chr 1: 21.54 – 21.67 Mb	Chr 4: 137.42 – 137.52 Mb
PubMed search	[1]	[2]

Endothelin converting enzyme 1, also known as ECE1, is a enzyme which in humans is encoded by the ECE1 gene.

Function

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.

Further reading

• Yorimitsu K, Moroi K, Inagaki N, et al. (1995). "Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2". Biochem. Biophys. Res. Commun. 208 (2): 721–7. doi:10.1006/bbrc.1995.1397. PMID 7695628. 
• Schmidt M, Kröger B, Jacob E, et al. (1995). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Lett. 356 (2–3): 238–43. doi:10.1016/0014-5793(94)01277-6. PMID 7805846. 
• Shimada K, Matsushita Y, Wakabayashi K, et al. (1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochem. Biophys. Res. Commun. 207 (2): 807–12. doi:10.1006/bbrc.1995.1258. PMID 7864876. 
• Valdenaire O, Rohrbacher E, Mattei MG (1996). "Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)". J. Biol. Chem. 270 (50): 29794–8. doi:10.1074/jbc.270.50.29794. PMID 8530372. 
• Matsuoka R, Sawamura T, Yamada K, et al. (1996). "Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1". Cytogenet. Cell Genet. 72 (4): 322–4. doi:10.1159/000134214. PMID 8641140. 
• Orzechowski HD, Richter CM, Funke-Kaiser H, et al. (1997). "Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells". J. Mol. Med. 75 (7): 512–21. doi:10.1007/s001090050136. PMID 9253714. 
• Schweizer A, Valdenaire O, Nelböck P, et al. (1998). "Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations". Biochem. J. 328 ( Pt 3) (Pt 3): 871–7. PMC 1218999. PMID 9396733. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218999. 
• Kido T, Sawamura T, Masaki T (1998). "The processing pathway of endothelin-1 production". J. Cardiovasc. Pharmacol. 31 Suppl 1: S13–5. doi:10.1097/00005344-199800001-00006. PMID 9595387. 
• Hofstra RM, Valdenaire O, Arch E, et al. (1999). "A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction". Am. J. Hum. Genet. 64 (1): 304–8. doi:10.1086/302184. PMC 1377732. PMID 9915973. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1377732. 
• Lee S, Lin M, Mele A, et al. (1999). "Proteolytic processing of big endothelin-3 by the kell blood group protein". Blood 94 (4): 1440–50. PMID 10438732. 
• Valdenaire O, Lepailleur-Enouf D, Egidy G, et al. (1999). "A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization". Eur. J. Biochem. 264 (2): 341–9. doi:10.1046/j.1432-1327.1999.00602.x. PMID 10491078. 
• Fahnoe DC, Johnson GD, Herman SB, Ahn K (2000). "Disulfide bonds in big ET-1 are essential for the specific cleavage at the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells". Arch. Biochem. Biophys. 373 (2): 385–93. doi:10.1006/abbi.1999.1586. PMID 10620363. 
• López-Ongil S, Senchak V, Saura M, et al. (2000). "Superoxide regulation of endothelin-converting enzyme". J. Biol. Chem. 275 (34): 26423–7. doi:10.1074/jbc.M000767200. PMID 10833511. 
• Hachiya A, Kobayashi T, Takema Y, Imokawa G (2002). "Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis". J. Biol. Chem. 277 (7): 5395–403. doi:10.1074/jbc.M105874200. PMID 11723113. 
• Inguimbert N, Coric P, Poras H, et al. (2002). "Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP)". J. Med. Chem. 45 (7): 1477–86. doi:10.1021/jm0005454. PMID 11906289. 
• MacLeod KJ, Husain RD, Gage DA, Ahn K (2003). "Constitutive phosphorylation of human endothelin-converting enzyme-1 isoforms". J. Biol. Chem. 277 (48): 46355–63. doi:10.1074/jbc.M207972200. PMID 12244060. 
• Muller L, Barret A, Etienne E, et al. (2003). "Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease". J. Biol. Chem. 278 (1): 545–55. doi:10.1074/jbc.M208949200. PMID 12393864. 
• Eckman EA, Watson M, Marlow L, et al. (2003). "Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme". J. Biol. Chem. 278 (4): 2081–4. doi:10.1074/jbc.C200642200. PMID 12464614. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Masatsugu K, Itoh H, Chun TH, et al. (2003). "Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress". Regul. Pept. 111 (1–3): 13–9. doi:10.1016/S0167-0115(02)00219-7. PMID 12609744. 
• Smollich M, Götte M, Yip GW, et al. (2007). "On the role of endothelin-converting enzyme 1 (ECE-1) and neprilysin in human breast cancer". Breast Cancer Res. Treat. 106 (3): 361–9. doi:10.1007/s10549-007-9516-9. PMID 17295044.