Endothelin receptor type A

Endothelin receptor type A
Identifiers
Symbols	EDNRA; ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR
External IDs	OMIM: 131243 MGI: 105923 HomoloGene: 1478 IUPHAR: ETA GeneCards: EDNRA Gene
Gene Ontology Molecular function • phosphatidylinositol phospholipase C activity • signal transducer activity • receptor activity • G-protein coupled receptor activity • endothelin receptor activity Cellular component • plasma membrane • integral to plasma membrane • membrane • T-tubule • nuclear membrane • membrane raft Biological process • patterning of blood vessels • response to hypoxia • in utero embryonic development • histamine secretion • positive regulation of protein phosphorylation • glomerular filtration • smooth muscle contraction • signal transduction • G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • activation of phospholipase C activity • elevation of cytosolic calcium ion concentration • activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway • Rho protein signal transduction • heart development • aging • respiratory gaseous exchange • cell proliferation • positive regulation of cell proliferation • neural crest cell development • response to organic cyclic compound • artery smooth muscle contraction • glucose transport • sensory perception of pain • negative regulation of cAMP biosynthetic process • response to lipopolysaccharide • specification of segmental identity, mandibular segment • vasoconstriction • positive regulation of odontogenesis • negative regulation of apoptotic process • penile erection • response to morphine • fibroblast proliferation • smooth muscle cell proliferation • regulation of epithelial cell proliferation • positive regulation of inflammatory response • positive regulation of release of sequestered calcium ion into cytosol • elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger • positive regulation of calcium ion transport • maternal process involved in parturition • head development • positive regulation of ERK1 and ERK2 cascade • cellular response to mechanical stimulus • positive regulation of neutrophil chemotaxis • positive regulation of kidney development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1909	13617
Ensembl	ENSG00000151617	ENSMUSG00000031616
UniProt	P25101	Q61614
RefSeq (mRNA)	NM_001166055.1	NM_010332.2
RefSeq (protein)	NP_001159527.1	NP_034462.1
Location (UCSC)	Chr 4: 148.4 – 148.47 Mb	Chr 8: 80.19 – 80.25 Mb
PubMed search	[1]	[2]

Endothelin receptor type A, also known as ET_A, is a human G protein-coupled receptor.

Interactions

Endothelin receptor type A has been shown to interact with HDAC7A and HTATIP.

See also

• Endothelin receptor

External links

• "Endothelin Receptors: ET_A". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2263. 

Further reading

• Arai H, Nakao K, Hosoda K, et al. (1993). "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]". Jpn. Circ. J. 56 Suppl 5: 1303–7. PMID 1291713. 
• Hosoda K, Nakao K, Tamura N, et al. (1992). "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor.". J. Biol. Chem. 267 (26): 18797–804. PMID 1326535. 
• Hayzer DJ, Rose PM, Lynch JS, et al. (1992). "Cloning and expression of a human endothelin receptor: subtype A.". Am. J. Med. Sci. 304 (4): 231–8. doi:10.1097/00000441-199210000-00002. PMID 1415318. 
• Hosoda K, Nakao K, Hiroshi-Arai, et al. (1991). "Cloning and expression of human endothelin-1 receptor cDNA.". FEBS Lett. 287 (1–2): 23–6. doi:10.1016/0014-5793(91)80007-P. PMID 1652463. 
• Cyr C, Huebner K, Druck T, Kris R (1992). "Cloning and chromosomal localization of a human endothelin ETA receptor". Biochem. Biophys. Res. Commun. 181 (1): 184–90. doi:10.1016/S0006-291X(05)81399-3. PMID 1659806. 
• Adachi M, Yang YY, Furuichi Y, Miyamoto C (1991). "Cloning and characterization of cDNA encoding human A-type endothelin receptor". Biochem. Biophys. Res. Commun. 180 (3): 1265–72. doi:10.1016/S0006-291X(05)81332-4. PMID 1719979. 
• Lin HY, Kaji EH, Winkel GK, et al. (1991). "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor". Proc. Natl. Acad. Sci. U.S.A. 88 (8): 3185–9. doi:10.1073/pnas.88.8.3185. PMC 51410. PMID 1849646. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=51410. 
• Takigawa M, Sakurai T, Kasuya Y, et al. (1995). "Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors". Eur. J. Biochem. 228 (1): 102–8. doi:10.1111/j.1432-1033.1995.tb20236.x. PMID 7882989. 
• Kobayashi S, Tang R, Wang B, et al. (1994). "Binding and functional properties of endothelin receptor subtypes in the human prostate". Mol. Pharmacol. 45 (2): 306–11. PMID 8114678. 
• Yang H, Tabuchi H, Furuichi Y, Miyamoto C (1993). "Molecular characterization of the 5'-flanking region of human genomic ETA gene". Biochem. Biophys. Res. Commun. 190 (2): 332–9. doi:10.1006/bbrc.1993.1052. PMID 8427579. 
• Elshourbagy NA, Korman DR, Wu HL, et al. (1993). "Molecular characterization and regulation of the human endothelin receptors". J. Biol. Chem. 268 (6): 3873–9. PMID 8440682. 
• Miyamoto Y, Yoshimasa T, Arai H, et al. (1996). "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts". Biochem. J. 313 (3): 795–801. PMC 1216980. PMID 8611157. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1216980. 
• Horstmeyer A, Cramer H, Sauer T, et al. (1996). "Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification". J. Biol. Chem. 271 (34): 20811–9. doi:10.1074/jbc.271.34.20811. PMID 8702836. 
• Freedman NJ, Ament AS, Oppermann M, et al. (1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity". J. Biol. Chem. 272 (28): 17734–43. doi:10.1074/jbc.272.28.17734. PMID 9211925. 
• Bourgeois C, Robert B, Rebourcet R, et al. (1997). "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3". J. Clin. Endocrinol. Metab. 82 (9): 3116–23. doi:10.1210/jc.82.9.3116. PMID 9284755. 
• Mao XQ, Gao PS, Roberts MH, et al. (1999). "Variants of endothelin-1 and its receptors in atopic asthma". Biochem. Biophys. Res. Commun. 262 (1): 259–62. doi:10.1006/bbrc.1999.1158. PMID 10448102. 
• Maggi M, Barni T, Fantoni G, et al. (2000). "Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons". J. Clin. Endocrinol. Metab. 85 (4): 1658–65. doi:10.1210/jc.85.4.1658. PMID 10770212. 
• Shraga-Levine Z, Sokolovsky M (2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific". Cell. Mol. Neurobiol. 20 (3): 305–17. doi:10.1023/A:1007010125316. PMID 10789830. 
• Lee HJ, Chun M, Kandror KV (2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". J. Biol. Chem. 276 (20): 16597–600. doi:10.1074/jbc.C000909200. PMID 11262386. 
• Paasche JD, Attramadal T, Sandberg C, et al. (2001). "Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways". J. Biol. Chem. 276 (36): 34041–50. doi:10.1074/jbc.M103243200. PMID 11382773. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.