Endothelium-derived relaxing factor
Endothelium-derived relaxing factor (EDRF) is produced and released by the endothelium to promote smooth muscle relaxation. The best-characterized is nitric oxide (NO). Some sources equate EDRF and nitric oxide.
It is released in response to a variety of chemical and physical stimuli. It causes the smooth muscle in the vessel wall to relax.
According to Furchgott's website at SUNY Downstate Medical Center, "...we are investigating whether the endothelium-derived relaxing factor (EDRF) is simply nitric oxide or a mixture of substances".
Although there is strong evidence that nitric oxide elicits vasodilation, there is some evidence tying this effect to neuronal rather than endothelial reactions.
- "endothelial-derived relaxing factor" at Dorland's Medical Dictionary
- "Robert Furchgott". Retrieved 2008-12-21.
- Chowdhary S, Townend JN (April 2001). "Nitric oxide and hypertension: not just an endothelium derived relaxing factor!". J Hum Hypertens 15 (4): 219–27. doi:10.1038/sj.jhh.1001165. PMID 11319669.