Enteroendocrine cell

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Enteroendocrine cells
Digestive hormones.jpg
Actions of the major digestive hormones secreted by enteroendocrine cells
Latin endocrinocyti gastroenteropancreatici
MeSH Enteroendocrine+cells
Code TH H3.04.02.0.00024
TH H3.08.01.0.00003

Enteroendocrine cells are specialized endocrine cells of the gastrointestinal tract and pancreas. They produce hormones in response to various stimuli gastrointestinal hormones or peptides and release them into the bloodstream for systemic effect, diffuse them as local messengers, or transmit them to the enteric nervous system to activate nervous responses.[1][2] Enteroendocrine cells of the intestine are the most numerous endocrine cells of the body.[3][4][5] In a sense they are known to act as chemoreceptors, initiating digestive actions and detecting harmful substances and initiating protective responses.[6][7] Enteroendocrine cells are located in the stomach, in the intestine and in the pancreas.

Intestinal enteroendocrine cells[edit]

Intestinal enteroendocrine cells are not clustered together but spread as single cells throughout the intestinal tract.[8] K-cells and L-cells secrete respectively the incretins gastric inhibitory peptide and glucagon-like peptide-1. Enterochromaffin cells are enteroendocrine and neuroendocrine cells with a close similarity to adrenomedullary chromaffin cells secreting serotonin.

Other hormones secreted include somatostatin, motilin, cholecystokinin, neurotensin, vasoactive intestinal peptide, and enteroglucagon.[9]

Gastric enteroendocrine cells[edit]

Gastric enteroendocrine cells are found at stomach glands, mostly at their base. The G cells secrete gastrin, post-ganglionic fibers of the vagus nerve can release gastrin-releasing peptide during parasympathetic stimulation to stimulate secretion. Enterochromaffin-like cells are enteroendocrine and neuroendocrine cells also known for their similarity to chromaffin cells secreting histamine, which gastrin stimulates.

Other hormones produced include cholecystokinin, somatostatin, vasoactive intestinal peptide, substance P, alpha and gamma-endorphin.[9][10]

Pancreatic enteroendocrine cells[edit]

Pancreatic enteroendocrine cells are located in the islets of Langerhans and produce most importantly the hormones insulin and glucagon. The autonomous nervous system strongly regulates their secretion, with parasympathetic stimulation stimulating insulin secretion and inhibiting glucagon secretion and sympathetic stimulation having opposite effect.[11]

Other hormones produced include somatostatin, pancreatic polypeptide, amylin and ghrelin.

Pathology[edit]

Rare and slow growing carcinoid and non-carcinoid tumors develop from these cells. When a tumor arises it has the capacity to secrete large volumes of hormones.[2][12]

See also[edit]

References[edit]

  1. ^ Rehfeld, Jens F. The New Biology of Gastrointestinal Hormones" Physiol. Rev 78: 1087–1108, 1998
  2. ^ a b Solcia, E; Capella, C; Buffa, R; Usellini, L; Fiocca, R; Frigerio, B; Tenti, P; Sessa, F (1981). "The diffuse endocrine-paracrine system of the gut in health and disease: ultrastructural features.". Scandinavian journal of gastroenterology. Supplement 70: 25–36. PMID 6118945. 
  3. ^ Ahlman, H; Nilsson, (2001). "The gut as the largest endocrine organ in the body.". Annals of Oncology. 12 Suppl 2: S63–8. doi:10.1093/annonc/12.suppl_2.s63. PMID 11762354. 
  4. ^ Schonhoff, SE; Giel-Moloney, M; Leiter, AB (June 2004). "Minireview: Development and differentiation of gut endocrine cells.". Endocrinology 145 (6): 2639–44. doi:10.1210/en.2004-0051. PMID 15044355. 
  5. ^ Moran, G. W.; Leslie, F. C.; Levison, S. E.; McLaughlin, J. T. (1 July 2008). "Review: Enteroendocrine cells: Neglected players in gastrointestinal disorders?". Therapeutic Advances in Gastroenterology 1 (1): 51–60. doi:10.1177/1756283X08093943. PMC 3002486. 
  6. ^ Sternini, C; Anselmi, L; Rozengurt, E (February 2008). "Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing.". Current Opinion in Endocrinology, Diabetes and Obesity 15 (1): 73–8. doi:10.1097/MED.0b013e3282f43a73. PMC 2943060. PMID 18185066. 
  7. ^ Sternini, C (February 2007). "Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing.". American journal of physiology. Gastrointestinal and liver physiology 292 (2): G457–61. doi:10.1152/ajpgi.00411.2006. PMID 17095755. 
  8. ^ Sternini, Catia; Anselmi, Laura; Rozengurt, Enrique (1 February 2008). "Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing". Current Opinion in Endocrinology, Diabetes and Obesity 15 (1): 73–78. doi:10.1097/MED.0b013e3282f43a73. PMC 2943060. PMID 18185066. 
  9. ^ a b Krause, WJ; Yamada, J; Cutts, JH (June 1985). "Quantitative distribution of enteroendocrine cells in the gastrointestinal tract of the adult opossum, Didelphis virginiana.". Journal of anatomy 140 (4): 591–605. PMC 1165084. PMID 4077699. 
  10. ^ Zverkov, IV; Vinogradov, VA; Smagin, VG (October 1983). "Endorphin-containing cells in the gastric antral mucosa in duodenal ulcer.". Biulleten' eksperimental'noi biologii i meditsiny 96 (10): 32–4. PMID 6194833. 
  11. ^ Kiba, T (August 2004). "Relationships between the autonomic nervous system and the pancreas including regulation of regeneration and apoptosis: recent developments.". Pancreas 29 (2): e51–8. doi:10.1097/00006676-200408000-00019. PMID 15257115. 
  12. ^ Warner, RR (May 2005). "Enteroendocrine tumors other than carcinoid: a review of clinically significant advances.". Gastroenterology 128 (6): 1668–84. doi:10.1053/j.gastro.2005.03.078. PMID 15887158. 

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