Enterotype

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An enterotype is a classification of living organisms based on its bacteriological ecosystem in the gut microbiome. The discovery of three human enterotypes was announced in the April 2011 issue of Nature by Peer Bork and his associates.[1] They found that enterotypes are not dictated by age, gender, body weight, or national divisions.[2] There are indications that long-term diet influences enterotype.[3]

Chimpanzees have enterotypes that are compositionally analogous to those found in humans. Using longitudinal samples, researchers found that the enterotype of an individual chimpanzees varied over time.[4]

Type 1 is characterized by high levels of Bacteroides, type 2 has few Bacteroides but Prevotella are common, and type 3 has high levels of Ruminococcus.[1][5][6]

References[edit]

  1. ^ a b Zimmer, Carl (20 April 2011). "Bacteria Divide People Into 3 Types, Scientists Say". The New York Times. Retrieved 21 April 2011. "a group of scientists now report just three distinct ecosystems in the guts of people they have studied." 
  2. ^ Arumugam M, Raes J, et al. (April 2011). "Enterotypes of the human gut microbiome". Nature 473 (7346): 174–80. doi:10.1038/nature09944. PMC 3728647. PMID 21508958. "Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific." 
  3. ^ Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, et al (2011). "Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes". Science 334 (6052): 105–108. doi:10.1126/science.1208344. PMC 3368382. PMID 21885731. 
  4. ^ Andrew H. Moeller, Patrick H. Degnan, Anne E. Pusey, Michael L. Wilson, Beatrice H. Hahn and Howard Ochman (November 13, 2012). "Chimpanzees and humans harbour compositionally similar gut enterotypes". Nature Communications 3 (1179): 1179. doi:10.1038/ncomms2159. 
  5. ^ Keim, Brandon (20 April 2011). "Gut-Bacteria Mapping Finds Three Global Varieties". Wired Magazine. Retrieved 21 April 2011. 
  6. ^ Coghlan, Andy (20 April 2011). "Each human has one of only three gut ecosystems". New Scientist. Retrieved 21 April 2011.