Eosinophil-derived neurotoxin

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Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
Protein RNASE2 PDB 1gqv.png
PDB rendering based on 1gqv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RNASE2 ; EDN; RNS2
External IDs OMIM131410 MGI1858238 HomoloGene121614 ChEMBL: 5120 GeneCards: RNASE2 Gene
EC number 3.1.27.5
RNA expression pattern
PBB GE RNASE2 206111 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6036 93726
Ensembl ENSG00000169385 ENSMUSG00000047222
UniProt P10153 Q8K196
RefSeq (mRNA) NM_002934 NM_053113
RefSeq (protein) NP_002925 NP_444343
Location (UCSC) Chr 14:
21.42 – 21.42 Mb
Chr 14:
51.26 – 51.26 Mb
PubMed search [1] [2]

Eosinophil-derived neurotoxin is an enzyme that in humans is encoded by the RNASE2 gene.[1][2][3]

The protein encoded by this gene is found in eosinophil granulocytes. It is closely related to the eosinophil cationic protein from which it diverged ~50 million years ago after the split between the old world and the new world monkeys.[4] It is relatively neutral and has cytotoxic properties. It is capable of reducing the activity of single strand RNA viruses in culture through its enzymatic activity. It also serves as an attractant to immune cells.

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References[edit]

  1. ^ Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491. 
  2. ^ Rosenberg HF, Tenen DG, Ackerman SJ (Jul 1989). "Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family". Proc Natl Acad Sci U S A 86 (12): 4460–4. doi:10.1073/pnas.86.12.4460. PMC 287289. PMID 2734298. 
  3. ^ "Entrez Gene: RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)". 
  4. ^ Rosenberg, Helene F. (2008-05-01). "RNase A ribonucleases and host defense: an evolving story". Journal of Leukocyte Biology 83 (5): 1079–1087. doi:10.1189/jlb.1107725. ISSN 1938-3673. PMC 2692241. Retrieved 2013-12-19. 

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