|Classification and external resources|
Eosinophilic esophagitis (eosinophilic oesophagitis), also known as allergic oesophagitis, is an allergic inflammatory condition of the esophagus that involves eosinophils, a type of white blood cell. Symptoms are swallowing difficulty, food impaction, and heartburn.
Eosinophilic esophagitis (EoE) was first described in children but also occurs in adults. The condition is not well understood, but food allergy may play a significant role. The treatment may consist of medication to suppress the immune response, but in severe cases it may be necessary to stretch the esophagus with an endoscopy procedure.
Signs and symptoms
EoE often presents with dysphagia (difficulty swallowing), food impaction, regurgitation or vomiting, and decreased appetite. In addition, young children with eosinophilic esophagitis may present with feeding difficulties and poor weight gain. It is more common in males, and affects both adults and children.
At a tissue level, EoE is characterised by a dense infiltrate with white blood cells of the eosinophil type into the epithelial lining of the esophagus. This is thought to be an allergic reaction against ingested food, based on the important role eosinophils play in allergic reactions. Eosinophils are inflammatory cells that release a variety of chemical signals which inflame the surrounding esophageal tissue. This results in the signs and symptoms of pain, visible redness on endoscopy, and a natural history that may include stricturing.
The diagnosis of EoE is typically made on the combination of symptoms and findings on diagnostic testing.
Prior to the development of the EE Diagnostic Panel, EoE could only be diagnosed if gastroesophageal reflux did not respond to a 6 week trial of twice-a-day high-dose proton-pump inhibitors (PPIs) or if a negative ambulatory pH study ruled out gastroesophageal reflux disease (GERD).
Endoscopically, ridges, furrows, or rings may be seen in the oesophageal wall. Sometimes, multiple rings may occur in the esophagus, leading to the term "corrugated esophagus" or "feline esophagus" due to similarity of the rings to the cat esophagus. Presence of white exudates in esophagus is also suggestive of the diagnosis. On biopsy taken at the time of endoscopy, numerous eosinophils can be seen in the superficial epithelium. A minimum of 15 eosinophils per high-power field are required to make the diagnosis. Eosinophilic inflammation is not limited to the oesophagus alone, and does extend though the whole gastrointestinal tract. Profoundly degranulated eosinophils may also be present, as may microabcesses and an expansion of the basal layer.
Radiologically, the term "ringed esophagus" has been used for the appearance of eosinophilic esophagitis on barium swallow studies to contrast with the appearance of transient transverse folds sometimes seen with esophageal reflux (termed "feline esophagus").
Treatment strategies include dietary modification to exclude food allergens, medical therapy, and mechanical dilatation of the esophagus.
The initial approach to the disorder is often allergy evaluation in an attempt to identify the allergens in the diet or environment that may be triggering the condition. If the offending agent is found, the diet is modified so that these allergens are eliminated. There are cases, especially in children, where there are multiple food allergies involved. Some patients require an elemental diet through the use of a specialty formula. Sticking to this diet and drinking the required amount of formula can be difficult. The use of feeding tubes in these situations is often required.
First-line therapy is with swallowed liquid corticosteroids and other anti-inflammatories, including fluticasone, a topical viscous budesonide oral suspension. Patients with severe symptoms despite these interventions may require oral corticosteroids such as methylprednisolone. Other anti-inflammatory agents have also been trialled, including leukotriene antagonists such as montelukast, anti-interleukins such as the anti-IL-5 monoclonal antibody mepolizumab, and antihistamines such as loratadine. Unfortunately, these have shown little clinical benefit.
Mechanical dilatation may be considered in severe cases of EoE that have progressed to esophageal stricture or severe stenosis. Dilatation is accomplished by passing dilators through the mouth and down the esophagus to gently expand its diameter. As the esophagus of patients with EoE is rather thin and delicate, care is taken not to perforate the esophagus by overzealous dilatation.
Despite EoE being historically thought of as refractory to proton pump inhibitor treatment, there is some recent evidence to suggest a significant proportion of patients suffering from EoE achieving remission following PPI therapy.
- Nurko, Samuel; Furuta, G T (2006). "Eosinophilic esophagitis". GI Motility online. doi:10.1038/gimo49.
- Blanchard C, Rothenberg ME (January 2008). "Basic pathogenesis of eosinophilic esophagitis". Gastrointest. Endosc. Clin. N. Am. 18 (1): 133–43; x. doi:10.1016/j.giec.2007.09.016. PMC 2194642. PMID 18061107.
- Noel, Richard J.; Putnam, Philip E.; Rothenberg, Marc E. (26 August 2004). "Eosinophilic esophagitis". New England Journal of Medicine 351 (9): 940–941. doi:10.1056/NEJM200408263510924.
- Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, Bonis P, Hassall E, Straumann A, Rothenberg ME; First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees. (Oct 2007). "Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.". Gastroenterology. 133 (4): 1342–63. doi:10.1053/j.gastro.2007.08.017. PMID 17919504.
- Samadi F, Levine MS, Rubesin SE, Katzka DA, Laufer I (April 2010). "Feline esophagus and gastroesophageal reflux". AJR Am J Roentgenol 194 (4): 972–6. doi:10.2214/AJR.09.3352. PMID 20308499.
- Furuta, GT; Liacouras, CA; Collins, MH; Gupta, SK; Justinich, C; Putnam, PE; Bonis, P; Hassall, E; Straumann, A; Rothenberg, ME; First International Gastrointestinal Eosinophil Research Symposium (FIGERS), Subcommittees (October 2007). "Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.". Gastroenterology 133 (4): 1342–63. doi:10.1053/j.gastro.2007.08.017. PMID 17919504.
- Zimmerman SL, Levine MS, Rubesin SE et al. (July 2005). "Idiopathic eosinophilic esophagitis in adults: the ringed esophagus". Radiology 236 (1): 159–65. doi:10.1148/radiol.2361041100. PMID 15983073.
- Molina-Infante, J; Hernandez-Alonso, M; Vinagre-Rodriguez, G; Martin-Noguerol, E (May 2011). "Proton pump inhibitors therapy for esophageal eosinophilia: simply following consensus guidelines.". Journal of gastroenterology 46 (5): 712–3; author reply 714–5. doi:10.1007/s00535-011-0388-8. PMID 21347633.
- Stewart, Michael J; Shaffer, Eldon; Urbanski, Stephan J; Beck, Paul L; Storr, Martin A (1 January 2013). "The association between celiac disease and eosinophilic esophagitis in children and adults". BMC Gastroenterology 13 (1): 96. doi:10.1186/1471-230X-13-96. PMID 23721294.
- CURED Foundation - Non-Profit for EGID Research
- American Partnership for Eosinophilic Disorders
- Families Affected By Eosinophilic Disorders
- Canadian Council of Eosinophilic Disorders
- Cincinnati Center for Eosinophilic Disorders
- Australian Support for Eosinophilic Disorders
- AEDESEO Asociación Espanola de Esofagitis Eosinofílica