Son of a veteran headmaster and educationist, Ademowo attended Immanuel College of Theology, Ibadan in 1969, he was made a deacon in 1972 and ordained priest in 1973. He graduated Bachelor of Arts majoring in Theology at the University of Ibadan in 1977 and earned his Master's Degree at the Obafemi Awolowo University (OAU), Ile-Ife and his Ph.D. degree at the same University. He was elected Bishop of Ilesa in 1989, and was translated to the Diocese of Lagos in 2000 as both Bishop and Archbishop of the province.
The Church of Nigeria (Anglican Communion) appointed Ademowo the new Dean of the Church in a press statement released 5 August 2010. He succeeded the Most Revd. Maxwell C. Anikwenwa incumbent Bishop of Awka Diocese who retired as Bishop, Archbishop and Dean on the 22nd of November 2010.
Ademowo was invested as Honorary Fellow of the Nigerian Academy of Letters (FNAL ) in 2006 and conferred in 2008 with the national honour of "Officer of the Order of the Niger (O.O.N.)" by the President of the Federal Republic of Nigeria, His Excellency Umaru Musa Yar'Adua on behalf of the government and people of Nigeria.
He is married to Oluranti I. Ademowo and they have children.
- "The Diocesan". Dioceseoflagos.org. 1948-07-29. Retrieved 2012-12-19.
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- "Our Baba Bishop and Archbishop Becomes the New Dean of the Church of Nigeria (Anglican Communion) | Facebook". En-gb.facebook.com. Retrieved 2012-12-19.
- "Citation for the Investiture of the Most Reverend Ephraim Adebola Ademowo as Honorary Fellow". Dioceseoflagos.org. Retrieved 2012-12-19.
- "Orders, Decorations and Medals - Medals by Country - Medals of Nigeria". Jeanpaulleblanc.com. Retrieved 2012-12-19.