The airfield was established in 1939 as Ephrata Army Air Base. It was used initially as a support airfield for bombing and gunnery ranges in the area (Seven Mile Gunnery School). Transferred to Fourth Air Force in 1940 as a group training airfield for B-17 Flying Fortress heavy bombardment units (including the 401st Bombardment Group), with new aircraft being obtained from Boeing near Seattle. Later it was reassigned to Second Air Force when heavy bombardment group training was reassigned to that command. It was also used by Air Technical Service Command as an aircraft maintenance and supply depot. The facility closed in late 1945 and was turned over to War Assets Administration (WAA) for disposal. It was transferred to Grant County and developed into a commercial airport in the late 1940s.
Parts of the 1989 Steven Spielberg film Always were filmed on the airport.
Ephrata Municipal Airport covers an area of 2,300 acres (931 ha) at an elevation of 1,276 feet (389 m) above mean sea level. It has three asphalt paved runways: 3/21 is 5,500 by 75 feet (1,676 x 23 m); 4/22 is 3,467 by 150 feet (1,057 x 46 m); 11/29 is 3,843 by 60 feet (1,171 x 18 m).
For the 12-month period ending June 28, 2010, the airport had 135,140 general aviation aircraft operations, an average of 370 per day. At that time there were 72 aircraft based at this airport: 24% single-engine, 7% multi-engine, and 69% glider.