Epi-lipoxin
From Wikipedia, the free encyclopedia
Epi-lipoxins are the 5R-epimers of lipoxins. These nonclassic eicosanoids are formed in vivo, in the presence of aspirin.[1] They play a counter-regulatory role in inflammation, serving as a stop signal.[2]
[edit] References
- ^ Clària J, Serhan CN (1995). "Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9475–9. doi:10.1073/pnas.92.21.9475. PMC 40824. PMID 7568157. http://www.pnas.org/cgi/reprint/92/21/9475. Retrieved 2007-11-01.
- ^ Serhan CN (2001). "Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side". Arch. Immunol. Ther. Exp. (Warsz.) 49 (3): 177–88. PMID 11478391.
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| Precursor |
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| Prostanoids |
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| Leukotrienes (LT) |
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| Nonclassic |
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| By function |
bronchoconstriction (PGD2, TXA2, LTC4, LTD4, LTE4)
vasoconstriction (PGF2α, TXA2, TXB2) · vasodilation (PGE2, PGI2, LTC4, LTD4, LTE4)
platelets: induce (TXA2) inhibit (PGD2, PGI2) · leukocytes: induce (TXA2, LTB4) inhibit (PGD2, PGE2)
fever stimulation: (PGE2)
labor stimulation: ( PGE2 (Dinoprostone), PGF2α (Dinoprost))
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