The epineurium is the outermost layer of connective tissue surrounding a peripheral nerve.[1] It is made of dense irregular connective tissue and usually contains multiple nerve fascicles as well as blood vessels which supply the nerve. Smaller branches of these blood vessels penetrate into the perineurium.
The epineurium is formed when the spinal nerve leaves the vertebral canal via the intervertebral foramen and two layers of the spinal meninges invaginate the nerve—arachnoid and dura—forming a "dural sleeve" which is the epineurium. A type of surgery that involves the epineurium is epineurial repair.
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- ^ McCracken, Thomas (1999). New Atlas of Human Anatomy. China: Metro Books. pp. 96–97. ISBN 1-5866-3097-0.
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The epineurium is made up of collagen fibers and forms a tough fibrous sheath. This sheath is continuous with the dura mater of the spinal column at the intervertebral foramen.***
