Epithelial dysplasia

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Epithelial dysplasia is the sum of various disturbances of epithelial proliferation and differentiation as seen microscopically. Individual cellular features of dysplasia are called epithelial atypia. Some authors[who?] favor the term "intraepithelial neoplasia".

Morphological changes[edit]

The changes that occur in epithelial dysplasia include:

  • Drop-shaped rete processes
  • Basal cell hyperplasia
  • Irregular epithelial stratification
  • Nuclear hyperchromatism
  • Increased nuclear-cytoplasmic ratio
  • Increased normal and abnormal mitosis
  • Enlarged nucleoli
  • Individual cell keratinization
  • Loss or reduction of cellular cohesion
  • Cellular pleomorphism
  • Loss of basal cell polarity
  • Anisocytosis
  • koilocytosis

Epithelial cell dysplasia is divided into three categories of severity: mild, moderate, and severe. Epithelial dysplasia becomes microinvasive squamous cell carcinoma once the tumor begins to invade nearby tissue.

See also[edit]