The Epoxyeicosatrienoic acids or EETs are signaling molecules formed by the action of Cytochrome P450 epoxygenase on 20-carbon essential fatty acids, such as arachidonic acid, from which it is produced by the enzyme epoxygenase. 
These nonclassic eicosanoids act as short-range hormones, (i.e. they are autocrine and paracrine mediators) of the cardiovascular system and kidney. They produce vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects. EETs are metabolized by the soluble epoxide hydrolase to the corresponding vicinal diol, or dihydroxyeicosatrienoic acids (DHETs), which are biologically less active.
Generally, EETs cause:
- Calcium release from intracellular stores
- Increased sodium-hydrogen antiporter activity
- Increased cell proliferation
- Decreased cyclooxygenase activity
Other effects are specific to certain cells or locations:
- EETs are cardioprotective after ischemic heart attack and reperfusion.
- They act in the corpus cavernosum to maintain penile erection.
- Specific epoxidation of EET sites produces endogenous PPARα agonists.
- Decreased release of somatostatin, insulin and glucagon from endocrine cells.
- Vasodilation and angiogenesis in blood vessels.
- Increased risk of tumor adhesion on endothelial cells
- Decreased platelet aggregation
- Walter F., PhD. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. p. 108. ISBN 1-4160-2328-3.
- Spector AA, Fang X, Snyder GD, Weintraub NL (January 2004). "Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function". Prog Lipid Res 43 (1): 55–90. doi:10.1016/S0163-7827(03)00049-3. PMID 14636671.
- Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ (August 2006). "Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury". Am. J. Physiol. Heart Circ. Physiol. 291 (2): H537–42. doi:10.1152/ajpheart.00071.2006. PMID 16473964.
- Jin L, Foss CE, Zhao X, et al. (March 2006). "Cytochrome P450 epoxygenases provide a novel mechanism for penile erection". FASEB J. 20 (3): 539–41. doi:10.1096/fj.05-4341fje. PMID 16415108.
- Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL (July 2007). "Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha". Drug Metab Dispos 37 (7): 1126–34. doi:10.1124/dmd.106.013839. PMID 17431031.
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