Epstein–Barr virus small nucleolar RNA 1

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Human herpesvirus 1 small nucleolar RNA
V-snoRNA1 SS.png
Sequence concservation of v-snoRNA1
Identifiers
Symbol v-snoRNA1
Rfam RF01516
Other data
RNA type snoRNA

V-snoRNA1 is a box CD-snoRNA[clarification needed] identified in B lymphocytes infected with the Epstein–Barr virus (human herpesvirus 4 (HHV-4)).[1] This snoRNA is the first known example of a snoRNA expressed from a viral genome.[2] It is homologous to eukaryotic snoRNAs because it contains the C and D boxes sequence motifs[clarification needed] but lacks a terminal stem-loop structure. The nucleolar localization of v-snoRNA1 was determined by in situ hybridization. V-snoRNA1 can form into a ribonucleoprotein complex (snoRNP) as co-immunoprecipitation (CoIP) assays showed that this snoRNA interacts with the snoRNA core proteins, fibrillarin, Nop56, Nop58.[clarification needed] It has also been proposed that this snoRNA may act as a miRNA-like precursor that is processed into 24-nucleotide-sized RNA fragments that target the 3'UTR[clarification needed] of viral DNA polymerase mRNA.[1]

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References[edit]

  1. ^ a b Hutzinger, R.; Feederle, R.; Mrazek, J.; Schiefermeier, N.; Balwierz, J.; Zavolan, M.; Polacek, N.; Delecluse, J.; Hüttenhofer, A. (Aug 2009). "Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genome" (Free full text). In Cullen, Bryan R. PLoS Pathogens 5 (8): e1000547. doi:10.1371/journal.ppat.1000547. ISSN 1553-7366. PMC 2718842. PMID 19680535.  edit
  2. ^ Gardner, P. P.; Bateman, A.; Poole, A. M. (2010). "SnoPatrol: How many snoRNA genes are there?". Journal of Biology 9 (1): 4. doi:10.1186/jbiol211. PMC 2871523. PMID 20122292.  edit

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