Erbin (protein)

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Erbb2 interacting protein
Protein ERBB2IP PDB 1mfg.png
PDB rendering based on 1mfg.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ERBB2IP ; ERBIN; HEL-S-78; LAP2
External IDs OMIM606944 MGI1890169 HomoloGene41282 GeneCards: ERBB2IP Gene
RNA expression pattern
PBB GE ERBB2IP 217941 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55914 59079
Ensembl ENSG00000112851 ENSMUSG00000021709
UniProt Q96RT1 Q80TH2
RefSeq (mRNA) NM_001006600 NM_001005868
RefSeq (protein) NP_001006600 NP_001005868
Location (UCSC) Chr 5:
65.22 – 65.38 Mb
Chr 13:
103.82 – 103.92 Mb
PubMed search [1] [2]

Erbb2 interacting protein (ERBB2IP) also known as Erbin is a protein which in humans is encoded by the ERBB2IP gene.[1] Discovered in 1997, Erbin is a 200kDa protein containing a PDZ domain.[2]

Function[edit]

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.[1]

Clinical significance[edit]

Erbin's C-terminal PDZ domain is able to bind to ErbB2, a protein tyrosine kinase which is often associated with poor prognosis in epidermal oncogenesis.[3] Erbin's N-terminal region has been shown to disrupt Ras to Raf binding and may be, through this action, a tumor suppressing protein.[4]

Interactions[edit]

Erbin (protein) has been shown to interact with HER2/neu,[5][6][7] Dystonin,[8] PKP4,[9][10][11] Mothers against decapentaplegic homolog 3[12] and ITGB4.[8]

References[edit]

  1. ^ a b "Entrez Gene: ERBB2IP erbb2 interacting protein". 
  2. ^ Borg JP, Marchetto S. et al. (2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor". Nat. Cell Biol. 2 (7): 407–414. doi:10.1038/35017038. PMID 10878805. 
  3. ^ Kolch, W. (2003). "Erbin: sorting out ErbB2 receptors or giving Ras a break?". Sci. STKE. 2003 (199): pe37. doi:10.1126/stke.2003.199.pe37. PMID 12966186. 
  4. ^ Dai P, Xiong WC, and Mei L. (2006). "Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex". J. Biol. Chem. 281 (2): 927–933. doi:10.1074/jbc.M507360200. PMID 16301319. 
  5. ^ Jaulin-Bastard, F; Saito H; Le Bivic A; Ollendorff V; Marchetto S; Birnbaum D; Borg J P (May 2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. (United States) 276 (18): 15256–63. doi:10.1074/jbc.M010032200. ISSN 0021-9258. PMID 11278603. 
  6. ^ Borg, J P; Marchetto S, Le Bivic A, Ollendorff V, Jaulin-Bastard F, Saito H, Fournier E, Adélaïde J, Margolis B, Birnbaum D (July 2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor". Nat. Cell Biol. (ENGLAND) 2 (7): 407–14. doi:10.1038/35017038. ISSN 1465-7392. PMID 10878805. 
  7. ^ Huang, Yang Z; Zang Mengwei; Xiong Wen C; Luo Zhijun; Mei Lin (January 2003). "Erbin suppresses the MAP kinase pathway". J. Biol. Chem. (United States) 278 (2): 1108–14. doi:10.1074/jbc.M205413200. ISSN 0021-9258. PMID 12379659. 
  8. ^ a b Favre, B; Fontao L; Koster J; Shafaatian R; Jaunin F; Saurat J H; Sonnenberg A; Borradori L (August 2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression". J. Biol. Chem. (United States) 276 (35): 32427–36. doi:10.1074/jbc.M011005200. ISSN 0021-9258. PMID 11375975. 
  9. ^ Izawa, Ichiro; Nishizawa Miwako; Tomono Yasuko; Ohtakara Kazuhiro; Takahashi Toshitada; Inagaki Masaki (May 2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells (England) 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. ISSN 1356-9597. PMID 12047349. 
  10. ^ Jaulin-Bastard, Fanny; Arsanto Jean-Pierre, Le Bivic André, Navarro Christel, Vély Frederic, Saito Hiroko, Marchetto Sylvie, Hatzfeld Mechthild, Santoni Marie-Josée, Birnbaum Daniel, Borg Jean-Paul (January 2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. (United States) 277 (4): 2869–75. doi:10.1074/jbc.M109652200. ISSN 0021-9258. PMID 11711544. 
  11. ^ Laura, Richard P; Witt Andrea S; Held Heike A; Gerstner Resi; Deshayes Kurt; Koehler Michael F T; Kosik Kenneth S; Sidhu Sachdev S; Lasky Laurence A (April 2002). "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF". J. Biol. Chem. (United States) 277 (15): 12906–14. doi:10.1074/jbc.M200818200. ISSN 0021-9258. PMID 11821434. 
  12. ^ Warner, Dennis R; Pisano M Michele; Roberts Emily A; Greene Robert M (March 2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. (Netherlands) 539 (1–3): 167–73. doi:10.1016/S0014-5793(03)00155-8. ISSN 0014-5793. PMID 12650946. 

Further reading[edit]

  • Nakajima D, Okazaki N, Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954. 
  • Kolch W (2003). "Erbin: sorting out ErbB2 receptors or giving Ras a break?". Sci. STKE 2003 (199): pe37. doi:10.1126/stke.2003.199.pe37. PMID 12966186. 
  • Nagase T, Ishikawa K, Kikuno R et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462. 
  • Borg JP, Marchetto S, Le Bivic A et al. (2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor". Nat. Cell Biol. 2 (7): 407–14. doi:10.1038/35017038. PMID 10878805. 
  • Jaulin-Bastard F, Saito H, Le Bivic A et al. (2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603. 
  • Huang YZ, Wang Q, Xiong WC, Mei L (2001). "Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95". J. Biol. Chem. 276 (22): 19318–26. doi:10.1074/jbc.M100494200. PMID 11279080. 
  • Favre B, Fontao L, Koster J et al. (2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression". J. Biol. Chem. 276 (35): 32427–36. doi:10.1074/jbc.M011005200. PMID 11375975. 
  • Saito H, Santoni MJ, Arsanto JP et al. (2001). "Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells". J. Biol. Chem. 276 (34): 32051–5. doi:10.1074/jbc.C100330200. PMID 11440998. 
  • Jaulin-Bastard F, Arsanto JP, Le Bivic A et al. (2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544. 
  • Laura RP, Witt AS, Held HA et al. (2002). "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF". J. Biol. Chem. 277 (15): 12906–14. doi:10.1074/jbc.M200818200. PMID 11821434. 
  • Izawa I, Nishizawa M, Tomono Y et al. (2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. 
  • Ohno H, Hirabayashi S, Iizuka T et al. (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826. 
  • Huang YZ, Zang M, Xiong WC et al. (2003). "Erbin suppresses the MAP kinase pathway". J. Biol. Chem. 278 (2): 1108–14. doi:10.1074/jbc.M205413200. PMID 12379659. 
  • Birrane G, Chung J, Ladias JA (2003). "Novel mode of ligand recognition by the Erbin PDZ domain". J. Biol. Chem. 278 (3): 1399–402. doi:10.1074/jbc.C200571200. PMID 12444095. 
  • Skelton NJ, Koehler MF, Zobel K et al. (2003). "Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain". J. Biol. Chem. 278 (9): 7645–54. doi:10.1074/jbc.M209751200. PMID 12446668. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Warner DR, Pisano MM, Roberts EA, Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3): 167–73. doi:10.1016/S0014-5793(03)00155-8. PMID 12650946. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.