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CAS number 50-14-6 YesY
PubChem 5280793
ChemSpider 4444351 YesY
DrugBank DB00153
KEGG C05441 YesY
ChEBI CHEBI:28934 YesY
ATC code A11CC01
Jmol-3D images Image 1
Molecular formula C28H44O
Molar mass 396.65 g/mol
Melting point 114–118 °C
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Ergocalciferol is a provitamin form of vitamin D, also called vitamin D2. In isolated manufactured formats, it is marketed under various names including Deltalin (Eli Lilly and Company), Drisdol (Sanofi-Synthelabo), and Calcidol (Patrin Pharma). Ergocalciferol is created when ultraviolet light activates ergosterol.[citation needed]

Ergocalciferol may be used as a vitamin D supplement, and a 2011 clinical guideline[1] considered it to be as effective as cholecalciferol (vitamin D3), which is produced naturally by the skin when exposed to ultraviolet light.



  • Cladina arbuscula specimens grown under different natural conditions: The contents of vitamin D3 range from 0.67 to 2.04 μg/g dry matter in the thalli of C. arbuscula specimens grown under different natural conditions, while provitamin D3 could not be detected. The ranges for provitamin D2 and vitamin D2 were 89-146 and 0.22-0.55 μg/g dry matter, respectively, while the contents of provitamin D3 were below the detection limit (0.01 μg/g dry matter).[2]

Fungus, from USDA nutrient database[3]

  • Mushrooms, portobello, exposed to ultraviolet light, raw: Vitamin D (D2 + D3): 11.2 µg (446 IU)
  • Mushrooms, portobello, exposed to ultraviolet light, grilled: Vitamin D (D2 + D3): 13.1 µg (524 IU)
  • Mushrooms, shiitake, dried: Vitamin D (D2 + D3): 3.9 μg (154 IU)
  • Mushrooms, shiitake, raw: Vitamin D (D2 + D3): 0.4 μg (18 IU)
  • Mushrooms, portobello, raw: Vitamin D (D2 + D3): 0.3 μg (10 IU)


  • Alfalfa (Medicago sativa subsp. sativa), shoot: 4.8 μg (192 IU) vitamin D2, 0.1 μg (4 IU) vitamin D3[4]

Ergocalciferol is produced in fungi synthetically through irradiation of ergosterol.[5] Human bioavailability of vitamin D2 from vitamin D2-enhanced button mushrooms via UV-B irradiation is effective in improving vitamin D status and not different from a vitamin D2 supplement.[6] Vitamin D2 from UV-irradiated yeast baked into bread is bioavailable.[7] By visual assessment or using a chromometer, no significant discoloration of irradiated mushrooms, as measured by the degree of "whiteness", was observed.[8] Claims have been made that a normal serving (approx. 3 oz or 1/2 cup, or 60 grams) of mushrooms treated with ultraviolet light provides vitamin D content to levels of 3,476 IU if exposed to just 5 minutes of UV light after being harvested.[9]

Research concerning efficacy of vitamin D2 and D3[edit]

Conflicting evidence exists for how similarly D2 and D3 behave in the body and whether they are equally active or efficient in production of 25-hydroxyvitamin D (25(OH)D), the active hormone. Some preliminary studies indicate D3 is more potent,[10][11] while others report equal efficacy.[1][12][13] Both forms appear to have similar efficacy in ameliorating rickets[14] and reducing the incidence of falls in elderly patients.[15]

The metabolism of each appears to be different, with the vitamin D binding protein possibly having greater affinity for 25(OH)D3 than for 25(OH)D2, as shown in one study.[10] Cholecalciferol (vitamin D3) is sensitive to UV radiation and rapidly, but reversibly, forms other sterols which can further irreversibly convert to ergosterol.[citation needed]

Preliminary research[edit]

One study found low vitamin D2 levels in patients with Alzheimer's disease,[16] but this observational study did not prove cause or effect related to ergocalciferol and vitamin D2 deficiency in the diet.


  1. ^ a b Holick, M. F.; Binkley, N. C.; Bischoff-Ferrari, H. A.; Gordon, C. M.; Hanley, D. A.; Heaney, R. P.; Murad, M. H.; Weaver, C. M. (2011). "Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline". Journal of Clinical Endocrinology & Metabolism 96 (7): 1911–1930. doi:10.1210/jc.2011-0385. PMID 21646368.  edit
  2. ^ Wang, T; Bengtsson, G; Kärnefelt, I; Björn, LO (2001). "Provitamins and vitamins D₂and D₃in Cladina spp. Over a latitudinal gradient: Possible correlation with UV levels". Journal of photochemistry and photobiology. B, Biology 62 (1–2): 118–22. doi:10.1016/S1011-1344(01)00160-9. PMID 11693362. 
  3. ^ "USDA nutrient database – use the keyword 'portabella' and then click submit". 
  4. ^ "Dr. Duke's Phytochemical and Ethnobotanical Databases". 
  5. ^ "Vitamin D: A Rapid Review: Vitamin D2 and/or Vitamin D3". 2008-06-30. Retrieved 2012-08-29. 
  6. ^
  7. ^ Hohman, E. E.; Martin, B. R.; Lachcik, P. J.; Gordon, D. T.; Fleet, J. C.; Weaver, C. M. (2011). "Bioavailability and Efficacy of Vitamin D2from UV-Irradiated Yeast in Growing, Vitamin D-Deficient Rats". Journal of Agricultural and Food Chemistry 59 (6): 2341–2346. doi:10.1021/jf104679c. PMC 3235799. PMID 21332187.  edit
  8. ^ Koyyalamudi, SR; Jeong, SC; Song, CH; Cho, KY; Pang, G (2009). "Vitamin D2 formation and bioavailability from Agaricus bisporus button mushrooms treated with ultraviolet irradiation". J Agric Food Chem 57 (8): 3351–5. doi:10.1021/jf803908q. PMID 19281276. 
  9. ^ "Bringing Mushrooms Out of the Dark". MSNBC. April 18, 2006. Retrieved 2007-08-06. 
  10. ^ a b Houghton, L.; Vieth, R. (2006). "The case against ergocalciferol (vitamin D2) as a vitamin supplement". The American Journal of Clinical Nutrition 84 (4): 694–697. PMID 17023693.  edit
  11. ^ Trang, H. M.; Cole, D. E.; Rubin, L. A.; Pierratos, A.; Siu, S.; Vieth, R. (1998). "Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2". The American journal of clinical nutrition 68 (4): 854–858. PMID 9771862.  edit
  12. ^ Holick, M. F.; Biancuzzo, R. M.; Chen, T. C.; Klein, E. K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W.; Ameri, A.; Tannenbaum, A. D. (2007). "Vitamin D2 is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D". Journal of Clinical Endocrinology & Metabolism 93 (3): 677–681. doi:10.1210/jc.2007-2308. PMC 2266966. PMID 18089691.  edit
  13. ^ Biancuzzo, R. M.; Young, A.; Bibuld, D.; Cai, M. H.; Winter, M. R.; Klein, E. K.; Ameri, A.; Reitz, R.; Salameh, W.; Chen, T. C.; Holick, M. F. (2010). "Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults". American Journal of Clinical Nutrition 91 (6): 1621–1626. doi:10.3945/ajcn.2009.27972. PMC 2869510. PMID 20427729.  edit
  14. ^ Thacher, TD; Fischer, PR; Obadofin, MO; Levine, MA; Singh, RJ; Pettifor, JM (2010). "Comparison of Metabolism of Vitamins D2 and D3 in Children with Nutritional Rickets". Journal of Bone and Mineral Research 25 (9): 1988–1995. doi:10.1002/jbmr.99. PMC 3153403. PMID 20499377. 
  15. ^ Fosnight, S. M.; Zafirau, W. J.; Hazelett, S. E. (2008). "Vitamin D Supplementation to Prevent Falls in the Elderly: Evidence and Practical Considerations". Pharmacotherapy 28 (2): 225–234. doi:10.1592/phco.28.2.225. PMID 18225968.  edit
  16. ^ Iltaf Shah; Petroczi, Andrea; Tabet, Naji; Klugman, Anthony; Isaac, Mokhtar; p. Naughton, Declan (2012). "Low 25OH Vitamin D2 Levels Found in Untreated Alzheimer's Patients, Compared to Acetylcholinesterase-Inhibitor Treated and Controls". Current Alzheimer Research 9 (9): 1069–1076. doi:10.2174/156720512803568975. ISSN 1567-2050. PMID 22876849. 

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