Erythro-3-hydroxyaspartate ammonia-lyase

erythro-3-hydroxyaspartate ammonia-lyase
Identifiers
EC number	4.3.1.20
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, an erythro-3-hydroxyaspartate ammonia-lyase (EC 4.3.1.20) is an enzyme that catalyzes the chemical reaction

erythro-3-hydroxy-Ls-aspartate $\rightleftharpoons$ oxaloacetate + NH₃

Hence, this enzyme has one substrate, erythro-3-hydroxy-Ls-aspartate, and two products, oxaloacetate and NH₃.

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming). Other names in common use include 3-hydroxyaspartate dehydratase, erythro-beta-hydroxyaspartate dehydratase, erythro-3-hydroxyaspartate dehydratase, erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating), and erythro-3-hydroxy-Ls-aspartate ammonia-lyase. It employs one cofactor, pyridoxal phosphate.

References

• Gibbs RG, Morris JG (1965). "Purification and properties of erythro-beta-hydroxyasparate dehydratase from Micrococcus denitrificans". Biochem. J. 97 (2): 547–54. PMC 1264673. PMID 16749162. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1264673.