An erythrogenic toxin is a toxin produced by strains of Streptococcus pyogenes, the primary cause of scarlet fever. Erythrogenic toxin is known to damage the plasma membranes of blood capillaries under the skin and produce a red skin rash (characteristic of scarlet fever). Past studies have shown that multiple variants of erythrogenic toxins may be produced, depending on the strain of S. pyogenes present in the host. A small percentage of strains may not produce a detectable toxin at all. Bacteriophage T12 infection of Streptococcus pyogenes enables the production of erythrogenic toxin A, and increases virulence. The erythrogenic toxin is also referred to in the literature as Streptococcal Pyogenic Exotoxin types A, B, and C (SPE-A, SPE-B, SPE-C).
- "Erythrogenic toxin". Biology-online.org. Retrieved 18 October 2010.
- "Causes". Scarlet fever. Mayo Clinic. Retrieved 18 October 2010.
- Tortora, Gerard; Funke, Berdell; Case, Christine (2013). Microbiology (11th ed.). Pearson. p. 439.
- Knöll; Srámek, Vrbová, Gerlach, Reichardt, Köhler (December 1991). "Scarlet fever and types of erythrogenic toxins produced by the infecting streptococcal strains". Zentralbl Bakteriol 276 (1): 94–106. doi:10.1016/s0934-8840(11)80223-9. PMID 1789905.
- McShan, WM; Tang, YF; Ferretti, JJ (1997). "Bacteriophage T12 of Streptococcus pyogenes integrates into the gene encoding a serine tRNA". Molecular Microbiology 23 (4): 719–28. doi:10.1046/j.1365-2958.1997.2591616.x. PMID 9157243.
- Schlievert, PM; Gray, ED (June 1989). "Group A streptococcal pyrogenic exotoxin (scarlet fever toxin) type A and blastogen A are the same protein.". Infection and immunity 57 (6): 1865–7. PMC 313370. PMID 2498210.
- Schlievert, PM (1989). "Role of toxic shock syndrome toxin 1 in toxic shock syndrome: overview.". Clinical Infectious Diseases. 11 Suppl 1: S107–9. doi:10.1093/clinids/11.supplement_1.s107. PMID 2648535.
- Schlievert, Patrick M (1989). "Analysis of Toxic Shock Syndrome Isolates Producing Staphylococcal Enterotoxins B and Cl with Use of Southern Hybridization and Immunologic Assays". Journal of Infectious Diseases 11: S75–S82. doi:10.1093/clinids/11.Supplement_1.S75.
|This molecular biology article is a stub. You can help Wikipedia by expanding it.|