ESE
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ESE or Ese may refer to:
- East-southeast, a cardinal direction
- Easy Serving Espresso Pod
- Ethical Sensory Extrovert
- European School of Economics
- European Society of Endocrinology
- Exonic splicing enhancer, an RNA sequence which guides splicing machinery
- Extensible Storage Engine
- Massachusetts Department of Elementary and Secondary Education
- Early streamer emission, a theory stating that if a lightning rod has a mechanism producing ionization near its tip, then its lightning capture area is greatly increased
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