|Origin||Province of Macerata, near Esanatoglia|
|Mouth||Adriatic Sea, near Falconara Marittima|
|Source elevation||1116 m|
|Avg. discharge||18 m³/s|
|Basin area||1,203 km²|
The source of the river is east of Monte Penna in the province of Macerata near the border with the province of Ancona. The river flows east past Esanatoglia and curves north by Matelica before crossing the border into the province of Ancona near Cerreto d'Esi. The river continues flowing north before curving northeast near Genga. It then flows northeast near Serra San Quirico, Maiolati Spontini, Castelplanio, Castelbellino, Jesi, Chiaravalle and Montemarciano before flowing into the Adriatic Sea near Falconara Marittima.
Since 1995, the area around the Esino has been permitted to produce red and white Italian DOC wines. Grapes are limited to a harvest yield of 12 tonnes/ha with the finished wines requiring a minimum alcohol level of 10.5%. Reds are a minimum 60% of Montepulciano and/or Sangiovese with other local grape varieties permitted to fill out of the rest. Whites are predominantly composed of Verdicchio (50-100%) with other local varieties permitted to fill out the rest.
- Richard J.A. Talbert, ed. (2000). Barrington Atlas of the Greek and Roman World: Map-By-Map Directory I. Princeton, NJ and Oxford, UK: Princeton University Press. p. 607. ISBN 0691049459.
- Hammond World Atlas (6 ed.). Hammond World Atlas Corporation. 2010. p. 71. ISBN 9780843715606.
- The Times Comprehensive Atlas of the World (13 ed.). London: Times Books. 2011. p. 76 O8. ISBN 9780007419135.
- P. Saunders Wine Label Language pg 158 Firefly Books 2004 ISBN 1-55297-720-X
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