The Esino is a river of c. 85 km in the Marche, central Italy. Its name could derive from the Latina Aesis, the ancient city of Iesi (or vice versa).
The river stems from the Monte Cafaggio, in the province of Macerata, at c. 1,000 m, and first flows through the comuni of Esanatoglia, Matelica and Cerreto d'Esi, and then flows into the province of Ancona. Subsequently it receives the waters of the Giano and, in the so-called Gola della Rossa ("Canyon of the Red"), of the Sentino. After running at slower speed through Serra San Quirico, Maiolati Spontini, Castelplanio and Cupramontana, the Esino reaches Iesi and Chiaravalle, flowing into the Adriatic Sea at Falconara Marittima.
Esino DOC 
Since 1995, the area around the Esino has been permitted to produce red and white Italian DOC wines. Grapes are limited to a harvest yield of 12 tonnes/ha with the finished wines requiring a minimum alcohol level of 10.5%. Reds are a minimum 60% of Montepulciano and/or Sangiovese with other local grape varieties permitted to fill out of the rest. Whites are predominantly composed of Verdicchio (50-100%) with other local varieties permitted to fill out the rest.
See also 
Coordinates: 43°39′N 13°22′E / 43.650°N 13.367°E