Estradiol cypionate

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Estradiol cypionate
Estradiol 17 beta-cypionate.svg
Systematic (IUPAC) name
(17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl 3-cyclopentylpropanoate
Clinical data
Legal status Prescription only
Routes Oral, IM
Identifiers
CAS number 313-06-4
ATC code None
PubChem CID 9403
ChemSpider 9033
Synonyms 17β-Estradiol-17-cypionate
Chemical data
Formula C26H36O3 
Mol. mass 396.562 g/mol

Estradiol cypionate (INN, USAN; Depo-Estradiol, Depofemin, Estradep, many others), or estradiol cipionate, is a synthetic ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen, estradiol.[1][2] It was first introduced in 1952 by Upjohn in the United States,[3] and has been in widespread use since. Estradiol cypionate is absorbed more slowly than estradiol itself, and for that reason, it can be administered less often.[4] Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate was found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate were found to last for 4–5 days and 7–8 days, respectively.[5]

See also[edit]

References[edit]

  1. ^ A. D. Roberts (1991). Dictionary of Steroids: Chemical Data, Structures, and Bibliographies. CRC Press. p. 415. ISBN 978-0-412-27060-4. Retrieved 20 May 2012. 
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 405. ISBN 978-3-88763-075-1. Retrieved 20 May 2012. 
  3. ^ Marshall Sittig (1 January 1988). Pharmaceutical Manufacturing Encyclopedia. William Andrew. pp. 575–576. ISBN 978-0-8155-1144-1. Retrieved 20 May 2012. 
  4. ^ Sriram. Medicinal Chemistry. Pearson Education India. p. 427. ISBN 978-81-317-0031-0. Retrieved 20 May 2012. 
  5. ^ Oriowo MA, Landgren BM, Stenström B, Diczfalusy E (April 1980). "A comparison of the pharmacokinetic properties of three estradiol esters". Contraception 21 (4): 415–24. PMID 7389356.