Estradiol cypionate
 |
|
|---|---|
| Systematic (IUPAC) name | |
| (17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl 3-cyclopentylpropanoate | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ℞ Prescription only |
| Routes | Oral, IM |
| Identifiers | |
| CAS number | 313-06-4 |
| ATC code | None |
| PubChem | CID 9403 |
| ChemSpider | 9033 |
| Synonyms | 17β-Estradiol-17-cypionate |
| Chemical data | |
| Formula | C26H36O3 |
| Mol. mass | 396.562 g/mol |
|
|
|
|
Estradiol cypionate (INN, USAN; Depo-Estradiol, Depofemin, Estradep, many others), or estradiol cipionate, is a synthetic ester, specifically the 3-cyclopentylpropanoyl ester, of the natural estrogen, estradiol.[1][2] It was first introduced in 1952 by Upjohn in the United States,[3] and has been in widespread use since. Estradiol cypionate is absorbed more slowly than estradiol itself, and for that reason, it can be administered less often.[4] Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate was found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate were found to last for 4–5 days and 7–8 days, respectively.[5]
See also [edit]
References [edit]
- ^ A. D. Roberts (1991). Dictionary of Steroids: Chemical Data, Structures, and Bibliographies. CRC Press. p. 415. ISBN 978-0-412-27060-4. Retrieved 20 May 2012.
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 405. ISBN 978-3-88763-075-1. Retrieved 20 May 2012.
- ^ Marshall Sittig (1 January 1988). Pharmaceutical Manufacturing Encyclopedia. William Andrew. pp. 575–576. ISBN 978-0-8155-1144-1. Retrieved 20 May 2012.
- ^ Sriram. Medicinal Chemistry. Pearson Education India. p. 427. ISBN 978-81-317-0031-0. Retrieved 20 May 2012.
- ^ Oriowo MA, Landgren BM, Stenström B, Diczfalusy E (April 1980). "A comparison of the pharmacokinetic properties of three estradiol esters". Contraception 21 (4): 415–24. PMID 7389356.
|
||||||||||||||||||||||||||||||||||||||||||||||||
 |
This article about a steroid is a stub. You can help Wikipedia by expanding it. |
