Estradiol valerate
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| Systematic (IUPAC) name | |
| (17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl valerate | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ℞ Prescription only |
| Routes | Oral, IM[1] |
| Identifiers | |
| CAS number | 979-32-8 |
| ATC code | None |
| PubChem | CID 13791 |
| ChemSpider | 13194 |
| Synonyms | 17β-Estradiol-17-valerate
pentanoate d'estra-1,3,5(10)-triène-3-ol-17β-yle |
| Chemical data | |
| Formula | C23H32O3 |
| Mol. mass | 356.498 g/mol |
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Estradiol valerate (INN, USAN; brand names Altadiol, Deladiol, Delestrogen, Estraval, Progynova, Valergen, many others), or oestradiol valerate (BAN), is a synthetic ester, specifically the 17-pentanoyl ester, of the natural estrogen, 17β-estradiol.[2][3] It was introduced in the 1950s, and along with estradiol benzoate and estradiol cypionate, has since become one of the most widely used esters of estradiol.[4] Upon ingestion, regardless of the route of administration, estradiol valerate behaves as a prodrug, being cleaved by esterases in blood plasma and the liver into 17β-estradiol and valeric acid.[5][6] However, compared to estradiol itself, estradiol valerate is absorbed more slowly and possesses a longer duration, especially when given in an oil solution via intramuscular injection (in which it acts as a depot), and as a result, can be administered less frequently.[7][8]
See also [edit]
References [edit]
- ^ Christoph Zink (1 January 1988). Dictionary of Obstetrics and Gynecology. Walter de Gruyter. p. 86. ISBN 978-3-11-085727-6. Retrieved 20 May 2012.
- ^ A. D. Roberts (1991). Dictionary of Steroids: Chemical Data, Structures, and Bibliographies. CRC Press. p. 415. ISBN 978-0-412-27060-4. Retrieved 20 May 2012.
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 405. ISBN 978-3-88763-075-1. Retrieved 20 May 2012.
- ^ Samuel S. C. Yen (1991). Reproductive endocrinology: physiology, pathophysiology, and clinical management. Saunders. ISBN 978-0-7216-3206-3. Retrieved 20 May 2012.
- ^ Düsterberg B, Nishino Y (December 1982). "Pharmacokinetic and pharmacological features of oestradiol valerate". Maturitas 4 (4): 315–24. PMID 7169965.
- ^ "Progynova 1mg (SPC) | Drugs.com" (HTML). Retrieved 2012-09-06.
- ^ Sriram. Medicinal Chemistry. Pearson Education India. p. 427. ISBN 978-81-317-0031-0. Retrieved 20 May 2012.
- ^ Oriowo MA, Landgren BM, Stenström B, Diczfalusy E (April 1980). "A comparison of the pharmacokinetic properties of three estradiol esters". Contraception 21 (4): 415–24. PMID 7389356.
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