Estrogen-related receptor beta

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Estrogen-related receptor beta
PBB Protein ESRRA image.jpg
PDB rendering based on 1lo1.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ESRRB ; DFNB35; ERR2; ERRb; ESRL2; NR3B2
External IDs OMIM602167 MGI1346832 HomoloGene69108 IUPHAR: NR3B2 ChEMBL: 3751 GeneCards: ESRRB Gene
Orthologs
Species Human Mouse
Entrez 2103 26380
Ensembl ENSG00000119715 ENSMUSG00000021255
UniProt O95718 Q61539
RefSeq (mRNA) NM_004452 NM_001159500
RefSeq (protein) NP_004443 NP_001152972
Location (UCSC) Chr 14:
76.31 – 76.5 Mb
Chr 12:
86.36 – 86.52 Mb
PubMed search [1] [2]

Estrogen-related receptor beta (ERR-β), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (EStrogen Related Receptor Beta) gene .[1]

Function[edit]

This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.[1]

References[edit]

Further reading[edit]

  • Giguère V, Yang N, Segui P, Evans RM (1988). "Identification of a new class of steroid hormone receptors.". Nature 331 (6151): 91–4. doi:10.1038/331091a0. PMID 3267207. 
  • Sladek R, Beatty B, Squire J et al. (1998). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene.". Genomics 45 (2): 320–6. doi:10.1006/geno.1997.4939. PMID 9344655. 
  • Enmark E, Pelto-Huikko M, Grandien K et al. (1998). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern.". J. Clin. Endocrinol. Metab. 82 (12): 4258–65. doi:10.1210/jc.82.12.4258. PMID 9398750. 
  • Chen F, Zhang Q, McDonald T et al. (1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR.". Gene 228 (1–2): 101–9. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763. 
  • Xie W, Hong H, Yang NN et al. (2000). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Mol. Endocrinol. 13 (12): 2151–62. doi:10.1210/me.13.12.2151. PMID 10598588. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Heilig R, Eckenberg R, Petit JL et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121. 
  • Gearhart MD, Holmbeck SM, Evans RM et al. (2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition". J. Mol. Biol. 327 (4): 819–32. doi:10.1016/S0022-2836(03)00183-9. PMID 12654265. 
  • Kruijver FP, Balesar R, Espila AM et al. (2003). "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution". J. Comp. Neurol. 466 (2): 251–77. doi:10.1002/cne.10899. PMID 14528452. 
  • Stossi F, Barnett DH, Frasor J et al. (2004). "Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors". Endocrinology 145 (7): 3473–86. doi:10.1210/en.2003-1682. PMID 15033914. 
  • Verdier-Sevrain S, Yaar M, Cantatore J et al. (2005). "Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism". FASEB J. 18 (11): 1252–4. doi:10.1096/fj.03-1088fje. PMID 15208259. 
  • Smith LH, Coats SR, Qin H et al. (2005). "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells". Circ. Res. 95 (3): 269–75. doi:10.1161/01.RES.0000136521.70093.f1. PMID 15217907. 
  • Liu PY, Christian RC, Ruan M et al. (2005). "Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease". J. Clin. Endocrinol. Metab. 90 (2): 1041–6. doi:10.1210/jc.2004-1211. PMID 15536156. 
  • Cheung CP, Yu S, Wong KB et al. (2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". J. Clin. Endocrinol. Metab. 90 (3): 1830–44. doi:10.1210/jc.2004-1421. PMID 15598686. 
  • Zhou W, Liu Z, Wu J et al. (2006). "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta". J. Clin. Endocrinol. Metab. 91 (2): 569–79. doi:10.1210/jc.2004-1957. PMID 16332939. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.