Estrogen-related receptor beta

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Estrogen-related receptor beta
PBB Protein ESRRA image.jpg
PDB rendering based on 1lo1.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ESRRB ; DFNB35; ERR2; ERRb; ESRL2; NR3B2
External IDs OMIM602167 MGI1346832 HomoloGene69108 IUPHAR: NR3B2 ChEMBL: 3751 GeneCards: ESRRB Gene
Species Human Mouse
Entrez 2103 26380
Ensembl ENSG00000119715 ENSMUSG00000021255
UniProt O95718 Q61539
RefSeq (mRNA) NM_004452 NM_001159500
RefSeq (protein) NP_004443 NP_001152972
Location (UCSC) Chr 14:
76.31 – 76.5 Mb
Chr 12:
86.36 – 86.52 Mb
PubMed search [1] [2]

Estrogen-related receptor beta (ERR-β), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (EStrogen Related Receptor Beta) gene .[1]


This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.[1]


Further reading[edit]

  • Giguère V, Yang N, Segui P, Evans RM (1988). "Identification of a new class of steroid hormone receptors.". Nature 331 (6151): 91–4. doi:10.1038/331091a0. PMID 3267207. 
  • Sladek R, Beatty B, Squire J, et al. (1998). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene.". Genomics 45 (2): 320–6. doi:10.1006/geno.1997.4939. PMID 9344655. 
  • Enmark E, Pelto-Huikko M, Grandien K, et al. (1998). "Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern.". J. Clin. Endocrinol. Metab. 82 (12): 4258–65. doi:10.1210/jc.82.12.4258. PMID 9398750. 
  • Chen F, Zhang Q, McDonald T, et al. (1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR.". Gene 228 (1–2): 101–9. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763. 
  • Xie W, Hong H, Yang NN, et al. (2000). "Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2". Mol. Endocrinol. 13 (12): 2151–62. doi:10.1210/me.13.12.2151. PMID 10598588. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121. 
  • Gearhart MD, Holmbeck SM, Evans RM, et al. (2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition". J. Mol. Biol. 327 (4): 819–32. doi:10.1016/S0022-2836(03)00183-9. PMID 12654265. 
  • Kruijver FP, Balesar R, Espila AM, et al. (2003). "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution". J. Comp. Neurol. 466 (2): 251–77. doi:10.1002/cne.10899. PMID 14528452. 
  • Stossi F, Barnett DH, Frasor J, et al. (2004). "Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors". Endocrinology 145 (7): 3473–86. doi:10.1210/en.2003-1682. PMID 15033914. 
  • Verdier-Sevrain S, Yaar M, Cantatore J, et al. (2005). "Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism". FASEB J. 18 (11): 1252–4. doi:10.1096/fj.03-1088fje. PMID 15208259. 
  • Smith LH, Coats SR, Qin H, et al. (2005). "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells". Circ. Res. 95 (3): 269–75. doi:10.1161/01.RES.0000136521.70093.f1. PMID 15217907. 
  • Liu PY, Christian RC, Ruan M, et al. (2005). "Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease". J. Clin. Endocrinol. Metab. 90 (2): 1041–6. doi:10.1210/jc.2004-1211. PMID 15536156. 
  • Cheung CP, Yu S, Wong KB, et al. (2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". J. Clin. Endocrinol. Metab. 90 (3): 1830–44. doi:10.1210/jc.2004-1421. PMID 15598686. 
  • Zhou W, Liu Z, Wu J, et al. (2006). "Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta". J. Clin. Endocrinol. Metab. 91 (2): 569–79. doi:10.1210/jc.2004-1957. PMID 16332939. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.