Estrogen receptor alpha

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Estrogen receptor 1
Protein ESR1 PDB 1a52.png
PDB rendering based on 1a52.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ESR1 ; ER; ESR; ESRA; ESTRR; Era; NR3A1
External IDs OMIM133430 MGI1352467 HomoloGene47906 IUPHAR: NR3A1 ChEMBL: 206 GeneCards: ESR1 Gene
Orthologs
Species Human Mouse
Entrez 2099 13982
Ensembl ENSG00000091831 ENSMUSG00000019768
UniProt P03372 P19785
RefSeq (mRNA) NM_000125 NM_007956
RefSeq (protein) NP_000116 NP_031982
Location (UCSC) Chr 6:
151.98 – 152.45 Mb
Chr 10:
4.61 – 5.01 Mb
PubMed search [1] [2]

Estrogen receptor alpha (ER-α), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. In humans, ER-α is encoded by the gene ESR1 (EStrogen Receptor 1).[1][2][3]

Structure[edit]

The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription.[4] Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.[5][1]

Coactivators[edit]

Coactivators of ER-α include:

Interactions[edit]

Estrogen receptor alpha has been shown to interact with:


References[edit]

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Further reading[edit]

  • McDonnell D, Norris J (2002). "Connections and regulation of the human estrogen receptor". Science 296 (5573): 1642–4. doi:10.1126/science.1071884. PMID 12040178. 
  • Simoncini T, Fornari L, Mannella P, Varone G, Caruso A, Liao J et al. (2003). "Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system. Interaction of estrogen receptor alpha with phosphatidylinositol 3-OH kinase". Steroids 67 (12): 935–9. doi:10.1016/S0039-128X(02)00040-5. PMID 12398989. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.