Hormone response element

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A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene that is able to bind a specific hormone receptor complex and therefore regulate transcription.[1] The sequence is most commonly a pair of inverted repeats separated by three nucleotides, which also indicates that the receptor binds as a dimer. Specifically, HRE responds to steroid hormones, as the activated steroid receptor is the transcription factor binding HRE. This upregulates transcription of genes signaled by the steroid hormone.

A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription.[2]

HRE are used in transgenic animal cells as inducers of gene expression.

References[edit]

  1. ^ "Steroid Hormone Receptors and their Response Elements". Retrieved 2006-11-09. 
  2. ^ Monty Krieger; Matthew P Scott; Matsudaira, Paul T.; Lodish, Harvey F.; Darnell, James E.; Lawrence Zipursky; Kaiser, Chris; Arnold Berk (2003). Molecular Cell Biology, Fifth Edition. San Francisco: W. H. Freeman. p. 973 pages. ISBN 0-7167-4366-3.