Etazocine

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Etazocine
Etazocine structure.svg
Systematic (IUPAC) name
1,2,3,4,5,6-hexahydro-6,11-diethyl-3-methyl-2,6-methano-3-benzazocin-8-ol
or
5,7-diethyl-2-hydroxy-2-methyl-6,7-benzomorphan
Clinical data
Legal status
  • Non-regulated
Identifiers
CAS number 34254-87-0
10286-45-0 ((-)-form (HCl))
ATC code None
PubChem CID 187767
ChemSpider 163214
Synonyms NIH-7856 ((±)-form);
GPA-208 ((-)-form);
GPA-2087 ((-)-form);
NIH-8178 ((-)-form);
FDA-0487 ((-)-form)
Chemical data
Formula C17H25NO 
Mol. mass 259.387 g/mol

Etazocine (NIH-7856) is an opioid analgesic of the benzomorphan family which was never marketed.[1][2] It acts as a partial agonist of the opioid receptors, with mixed agonist and antagonist effects.[1] In animal studies, it was shown to induce analgesia, dependency, and respiratory depression, with overall effects similar to those of morphine, but with substantially reduced potency in comparison.[1][2][3]

See also[edit]

References[edit]

  1. ^ a b c National Research Council (U.S.). Committee on Problems of Drug Dependence; American Medical Association. Committee on Alcoholism and Drug Dependence; American Medical Association. Council on Mental Health; National Academy of Sciences (U.S.) (1969). Bulletin, problems of drug dependence. National Academies. pp. 5820–5821. NAP:10503. Retrieved 22 April 2012. 
  2. ^ a b Smethurst PW, Forrest WH, Hayden J (December 1971). "The respiratory effects of a potent analgesic (GPA 2087) in man". British Journal of Anaesthesia 43 (12): 1129–35. doi:10.1093/bja/43.12.1129. PMID 5156297. 
  3. ^ National Research Council (U.S.). Committee on Problems of Drug Dependence (1970). Report of the annual scientific meeting. National Research Council. Retrieved 22 April 2012.