Ethanolamine-O-sulfate

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Ethanolamine-O-sulfate[1]
Ethanolamine-O-sulfate.png
Names
IUPAC name
2-Aminoethyl hydrogen sulfate
Other names
Aminoethyl sulfate; 2-Aminoethyl hydrogen sulphate; Sulfuric acid mono 2-aminoethyl ester; WAS-34
Identifiers
Abbreviations EOS
926-39-6 YesY
ChemSpider 63409 N
Jmol-3D images Image
PubChem 5245535
Properties
C2H7NO4S
Molar mass 141.15 g·mol−1
Melting point 277 °C (531 °F; 550 K) (decomposes)
Hazards
R-phrases R22 R36/37/38
S-phrases S26 S36
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Ethanolamine-O-sulfate (EOS) is an ester of sulfuric acid and ethanolamine. EOS is a GABA transaminase inhibitor which prevents the metabolism of GABA.[2] It is used as a biochemical tool in studies involving GABA.

EOS is also a diuretic[3] and an anticonvulsant.[4]

References[edit]

  1. ^ 2-Aminoethyl hydrogen sulfate at Sigma-Aldrich
  2. ^ Gudelsky G A; Apud J A; Masotto C; Locatelli V; Cocchi D; Racagni G; Muller E E (1983). "Ethanolamine-O-sulfate enhances gamma-aminobutyric acid secretion into hypophysial portal blood and lowers serum prolactin concentrations". Neuroendocrinology 37 (5): 397–9. doi:10.1159/000123580. PMID 6646351. 
  3. ^ German Patent DE2345291: Diuretic aminoalkyl sulfates; Somani, Pitambar; Martin, Donald Lyons (1974)
  4. ^ Anlezark, Gill; Horton, Roger W.; Meldrum, Brian S.; Sawaya, M. Christina B. (1976). "Anticonvulsant action of ethanolamine-O-sulfate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures". Biochemical Pharmacology 25 (4): 413–417. doi:10.1016/0006-2952(76)90343-9. PMID 779794.