Ethanolamine ammonia-lyase

ethanolamine ammonia-lyase
Identifiers
EC number	4.3.1.7
CAS number	9054-69-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, an ethanolamine ammonia-lyase (EC 4.3.1.7) is an enzyme that catalyzes the chemical reaction

ethanolamine $\rightleftharpoons$ acetaldehyde + NH₃

Hence, this enzyme has one substrate, ethanolamine, and two products, acetaldehyde and NH₃.

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is ethanolamine ammonia-lyase (acetaldehyde-forming). This enzyme is also called ethanolamine deaminase. This enzyme participates in glycerophospholipid metabolism. It employs one cofactor, adenosylcobalamin.

Structural studies

As of early 2011, several structures have been solved for this class of enzymes. The first structure solved was the active site containing EutB subunit of EAL from Listeria monocytogenes with the PDB accession code 2QEZ. Later, more structures have became available from Escherichia coli that include both EAL subunits bound to various ligands.

References

• Bradbeer C (1965). "The clostridial fermentations of choline and ethanolamine. 1 Preparation and properties of cell-free extracts". J. Biol. Chem. 240 (12): 4669–74. PMID 5846987. 
• Bradbeer C (1965). "The clostridial fermentations of choline and ethanolamine. II Requirement for a cobamide coenzyme by an ethanolamine deaminase". J. Biol. Chem. 240 (12): 4675–81. PMID 5846988. 
• Kaplan BH, Stadtman ER (1968). "Ethanolamine deaminase, a cobamide coenzyme-dependent enzyme. I Purification, assay, and properties of the enzyme". J. Biol. Chem. 243 (8): 1787–93. PMID 4297225.