Eugene Lindsay Opie
|Eugene Lindsay Opie|
Eugene Lindsay Opie, in 1903
|Born||5 July 1873
|Died||12 March 1971 (age 97)
Bryn Mawr, Pennsylvania
|Fields||Medicine & Pathology|
|Institutions||Johns Hopkins University, Rockefeller Institute, Washington University, Cornell University Medical School, University of Pennsylvania|
|Alma mater||Johns Hopkins University|
|Doctoral advisor||William H. Welch|
|Known for||Research on diabetes mellitus & tuberculosis|
Eugene Lindsay Opie, M.D. (5 July 1873 – 12 March 1971) was an American physician and pathologist who conducted important research on the causes, transmission, and diagnosis of tuberculosis and on immunization against the disease. He served as professor of pathology at several U.S. medical schools, as well as Dean of the Washington University School of Medicine (St. Louis, Missouri).
Education & early career 
Eugene Opie was born in Staunton, Virginia on July 5, 1873. His father, Thomas, was an obstetrician-gynecologist, and one of the founders and deans of the University of Maryland College of Medicine in Baltimore. Eugene attended the Johns Hopkins University (JHU), both as an undergraduate and a medical student. He received an A.B. degree in 1893, and was in the first graduating class of the JHU medical school, earning the M.D. degree in 1897. At least two other members of his class of 17 men also went on to pathology chairmanships or medical school deanships; namely, Charles Russell Bardeen and William George MacCallum.
Under the tutelage of the renowned pathologist William H. Welch, Opie developed a special affinity for tissue pathology. As a medical student, he observed consistent morphological alterations in the pancreatic islets of Langerhans in patients with diabetes mellitus – an observational epiphany that shed meaningful light on the pathogenesis of that disease. Eugene stayed on at JHU after completing medical school, to receive additional training in pathology from Welch. Opie continued his work on pancreatic diseases, establishing the relationship between obstruction of the ampulla of Vater (e.g., by gallstones) and the subsequent development of acute pancreatitis.
In 1904, Opie moved to New York City to work at the Rockefeller Institute, with a focus on the enzymatic constituents of leukocytes and their role in inflammatory conditions. He concurrently served as a "visiting" pathologist at Columbia-Presbyterian Hospital, and was named as an editor of the Journal of Experimental Medicine and the Proceedings of the Society for Experimental Biology.
Years at Washington University & Military Service 
In 1910, Opie was appointed as the Chair of Pathology at Washington University School of Medicine (WUSM) in St. Louis. He was asked to serve as Dean of the school from 1912 to 1915, presiding over a significant expansion of its physical facilities, scientific mission, and curriculum. When the United States entered World War I, Opie took a leave of absence from WUSM to enter the U.S. Army. He served in France as a Colonel (O6) in the Medical Corps, with special work on infectious diseases, and prevention thereof, among allied soldiers. Significant new data were accrued on influenza, tuberculosis, and "trench fever" (bartonellosis) during that time. Upon returning to civilian life, Opie continued his duties at WUSM until 1923.
Research on tuberculosis 
Opie narrowed his general interest in infectious disease to focus on tuberculosis, an international scourge in the early part of the 20th century. In 1923 he became the Director of the Phipps Institute for the Study & Treatment of Tuberculosis at the University of Pennsylvania in Philadelphia. A concomitant appointment as Professor of Pathology was also given to him. Through Opie's work over the next decade, much was learned about the modes of tuberculous infection in children and adults, as well as aspects of immunity, hypersensitivity, and cellular defenses regarding that disease. Opie moved to Cornell University Medical Center in New York in 1932, to continue his research. There, again as Chair of the Pathology department, he recruited several young pathologists – including Robert A. Moore, D. Murray Angevine, Jules Freund, and others – who would all go on to distinguish themselves as renowned investigators in their own rights. Like Opie, Moore also served as chair of pathology and dean of the medical school at Washington University in the 1940s and 1950s.
Eugene Opie retired from full-time professional work in pathology in 1941. Nevertheless, that was certainly not the end of his scientific endeavors. Opie again worked at the Rockefeller Institute as a "guest investigator" for the next 28 years. Peer-reviewed manuscripts bore his name as an author until 1970. In addition to infections, Opie did work on hepatic carcinogenesis, alterations in nucleic acid content in various disease states, and tissue fluid flux.
Eugene Opie served as the President of the American Association of Pathologists & Bacteriologists; the American Society for Experimental Pathology, the National Tuberculosis Association; the American Association of Immunologists; and the Harvey Society. He was awarded honorary doctorates from Yale University, Rockefeller University, and Washington University. Other accolades included the Weber-Parks Medal, the 1959 Jessie Stevenson Kovalenko Medal from the U.S. National Academy of Sciences, the 1960 Academy Medal for Distinguished Contributions in Biomedical Science from the New York Academy of Medicine, and the T. Duckett Jones Award.
Opie first married Gertrude Lovat Simpson on August 6, 1902, and had four children with her: Thomas Lindsay, Anne Lovat, Helen Lovat and Gertrude Eugenie. Seven years after Gertrude's death in 1909, he married her sister Margaret Lovat Simpson on September 16, 1916.
- "Eugene Lindsay Opie experimental pathologist". JAMA 199 (6): 420–1. February 1967. doi:10.1001/jama.1967.03120060118026. PMID 5334599. "Eugene L. Opie was the son of Thomas Opie, one of the founders of the College of Physicians and Surgeons of Baltimore, and professor of obstetrics and gynecology in the school and dean of its faculty for 33 years. Eugene was born in 1873 in Staunton, Va, where his mother was spending the summer to escape the heat of the city. Opie attended public schools in Baltimore and in 1893 received his bachelor of arts degree from Johns Hopkins University.1 After one year at the College of Physicians and Surgeons, he transferred to Johns Hopkins Medical School and in 1897 received the MD degree as a member of the first graduating class. Influenced particularly by William H. Welch, professor of pathology, and William S. Thayer, of the department of medicine, and with the aid of the microscope and laboratory animals, he became interested in the experimental study of disease."
- Kidd, JG (December 1971). "Eugene Lindsay Opie, MD, 1873-1971". The American Journal of Pathology 65 (3): 483–92. PMC 2047596. PMID 4941067.
- "The William G. MacCallum Collection". Johns Hopkins Medical Institutions. Retrieved 29 September 2009.
- Opie EL (1900). "On the histology of the islands of Langerhans of the pancreas". Bulletin of the Johns Hopkins Hospital 11: 205–209.
- Opie EL (1901). "The etiology of acute hemorrhagic pancreatitis". Bulletin of the Johns Hopkins Hospital 12: 182–188.
- Opie, Eugene L. (1910). "Inflammation". Archives of Internal Medicine V (6): 541–568.
- Op cit. Ref. 2
- Angevine, DM (January 1963). "Comments on the life of Eugene Lindsay Opie". Laboratory Investigation 12: 3–7. PMID 14013173.
- Opie, Eugene L.; Blake, Florence Guinness; Rivers, Andrew B.; Small, J. (1921). Epidemic Respiratory Disease. H. Kimpton. OCLC 429786627.[page needed]
- Long, ER (1974). "Eugene Lindsay Opie". Biographical memoirs. National Academy of Sciences (U.S.) 47: 293–320. PMID 11615627.
- Opie, EL (Spring 1970). "Adoption of standards of the best medical schools of Western Europe by those of the United States". Perspectives in Biology and Medicine 13 (3): 309–42. PMID 5427103.
- Opie, EL; Lynch, CJ; Tershakovec, M (April 1970). "Sclerosis of the mesenteric arteries of rats. Its relation to longevity and inheritance". Archives of Pathology 89 (4): 306–13. PMID 5461632.
- Opie, E. L.; Lavin, GI (June 1946). "LOCALIZATION OF RIBONUCLEIC ACID IN THE CYTOPLASM OF LIVER CELLS". Journal of Experimental Medicine 84 (1): 107–12. doi:10.1084/jem.84.1.107. PMC 2135636. PMID 19871549.
- "The Academy Medal for Distinguished Contributions in Biomedical Science". New York Academy of Medicine. Retrieved February 19, 2011.
- Esmond R. Long (1975). "Chapter 8 - Eugene Lindsay Opie". Biographical Memoirs 47. National Academy of Sciences. pp. 292–321. ISBN 0-309-02245-2. Retrieved March 24, 2011.
- "Eugene Opie Papers". American Philosophical Society. Retrieved March 24, 2011.
- "Dr. Eugene Opie, Researcher, Dies. Pathologist, 97, Died. Early Studies on Diabetes". New York Times. March 13, 1971. Retrieved 2010-03-22. "Dr. Eugene Lindsay Opie, a pathologist, bacteriologist, medical school administrator and pioneer researcher on the cause Of diabetes, tuberculosis and other diseases, died yesterday in the Bryn Mawr (Pa.) Hospital. He was 97 years old. Despite his age, Dr. Opie had continued to ..."
See also