Eukaryotic translation initiation factor 4 gamma

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Eukaryotic translation initiation factor 4 gamma, 1
Protein EIF4G1 PDB 1ug3.png
PDB rendering based on 1ug3.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EIF4G1 ; EIF-4G1; EIF4F; EIF4G; EIF4GI; P220; PARK18
External IDs OMIM600495 MGI2384784 HomoloGene110725 ChEMBL: 1741197 GeneCards: EIF4G1 Gene
RNA expression pattern
PBB GE EIF4G1 208624 s at tn.png
PBB GE EIF4G1 208625 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1981 208643
Ensembl ENSG00000114867 ENSMUSG00000045983
UniProt Q04637 Q6NZJ6
RefSeq (mRNA) NM_001194946 NM_001005331
RefSeq (protein) NP_001181875 NP_001005331
Location (UCSC) Chr 3:
184.03 – 184.05 Mb
Chr 16:
20.67 – 20.69 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.[1][2]

Function[edit]

The protein encoded by this gene is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.[3]

Interactions[edit]

Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1,[4] EIF4A1,[5][6][7] EIF4E,[6][7][8][9][10] MKNK2[11] and PABPC1.[12]

See also[edit]

References[edit]

  1. ^ Yan R, Rychlik W, Etchison D, Rhoads RE (Nov 1992). "Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma". The Journal of Biological Chemistry 267 (32): 23226–31. PMID 1429670. 
  2. ^ Imataka H, Sonenberg N (Dec 1997). "Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A". Molecular and Cellular Biology 17 (12): 6940–7. PMC 232551. PMID 9372926. 
  3. ^ "Entrez Gene: EIF4G1 eukaryotic translation initiation factor 4 gamma, 1". 
  4. ^ Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". The EMBO Journal 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMC 1171121. PMID 9878069. 
  5. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  6. ^ a b Connolly E, Braunstein S, Formenti S, Schneider RJ (May 2006). "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells". Molecular and Cellular Biology 26 (10): 3955–65. doi:10.1128/MCB.26.10.3955-3965.2006. PMC 1489005. PMID 16648488. 
  7. ^ a b Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (Apr 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". The EMBO Journal 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. PMC 1440840. PMID 16541103. 
  8. ^ Vary TC, Jefferson LS, Kimball SR (Dec 1999). "Amino acid-induced stimulation of translation initiation in rat skeletal muscle". The American Journal of Physiology 277 (6 Pt 1): E1077–86. PMID 10600798. 
  9. ^ Mader S, Lee H, Pause A, Sonenberg N (Sep 1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins". Molecular and Cellular Biology 15 (9): 4990–7. PMC 230746. PMID 7651417. 
  10. ^ Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M et al. (Apr 2000). "Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase". The Journal of Biological Chemistry 275 (15): 10779–87. doi:10.1074/jbc.275.15.10779. PMID 10753870. 
  11. ^ Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG et al. (Aug 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Molecular and Cellular Biology 23 (16): 5692–705. doi:10.1128/MCB.23.16.5692-5705.2003. PMC 166352. PMID 12897141. 
  12. ^ Imataka H, Gradi A, Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". The EMBO Journal 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202. 

Further reading[edit]