Eukaryotic translation initiation factor 4 gamma

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Eukaryotic translation initiation factor 4 gamma, 1
Protein EIF4G1 PDB 1ug3.png
PDB rendering based on 1ug3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EIF4G1 ; EIF-4G1; EIF4F; EIF4G; EIF4GI; P220; PARK18
External IDs OMIM600495 MGI2384784 HomoloGene110725 ChEMBL: 1741197 GeneCards: EIF4G1 Gene
RNA expression pattern
PBB GE EIF4G1 208624 s at tn.png
PBB GE EIF4G1 208625 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1981 208643
Ensembl ENSG00000114867 ENSMUSG00000045983
UniProt Q04637 Q6NZJ6
RefSeq (mRNA) NM_001194946 NM_001005331
RefSeq (protein) NP_001181875 NP_001005331
Location (UCSC) Chr 3:
184.03 – 184.05 Mb
Chr 16:
20.67 – 20.69 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.[1][2]

The protein encoded by this gene is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.[3]


Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1,[4] EIF4A1,[5][6][7] EIF4E,[6][7][8][9][10] MKNK2[11] and PABPC1.[12]

See also[edit]


  1. ^ Yan R, Rychlik W, Etchison D, Rhoads RE (December 1992). "Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma". J Biol Chem 267 (32): 23226–31. PMID 1429670. 
  2. ^ Imataka H, Sonenberg N (December 1997). "Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A". Mol Cell Biol 17 (12): 6940–7. PMC 232551. PMID 9372926. 
  3. ^ "Entrez Gene: EIF4G1 eukaryotic translation initiation factor 4 gamma, 1". 
  4. ^ Pyronnet, S; Imataka H; Gingras A C; Fukunaga R; Hunter T; Sonenberg N (January 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. (ENGLAND) 18 (1): 270–9. doi:10.1093/emboj/18.1.270. ISSN 0261-4189. PMC 1171121. PMID 9878069. 
  5. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  6. ^ a b Connolly, Eileen; Braunstein Steve; Formenti Silvia; Schneider Robert J (May 2006). "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells". Mol. Cell. Biol. (United States) 26 (10): 3955–65. doi:10.1128/MCB.26.10.3955-3965.2006. ISSN 0270-7306. PMC 1489005. PMID 16648488. 
  7. ^ a b Harris, Thurl E; Chi An; Shabanowitz Jeffrey; Hunt Donald F; Rhoads Robert E; Lawrence John C (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. (England) 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. ISSN 0261-4189. PMC 1440840. PMID 16541103. 
  8. ^ Vary, T C; Jefferson L S; Kimball S R (December 1999). "Amino acid-induced stimulation of translation initiation in rat skeletal muscle". Am. J. Physiol. (UNITED STATES) 277 (6 Pt 1): E1077–86. ISSN 0002-9513. PMID 10600798. 
  9. ^ Mader, S; Lee H; Pause A; Sonenberg N (September 1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins". Mol. Cell. Biol. (UNITED STATES) 15 (9): 4990–7. ISSN 0270-7306. PMC 230746. PMID 7651417. 
  10. ^ Kumar, V; Sabatini D, Pandey P, Gingras A C, Majumder P K, Kumar M, Yuan Z M, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S (April 2000). "Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase". J. Biol. Chem. (UNITED STATES) 275 (15): 10779–87. doi:10.1074/jbc.275.15.10779. ISSN 0021-9258. PMID 10753870. 
  11. ^ Scheper, Gert C; Parra Josep L; Wilson Mary; Van Kollenburg Barbara; Vertegaal Alfred C O; Han Ze-Guang; Proud Christopher G (August 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Mol. Cell. Biol. (United States) 23 (16): 5692–705. doi:10.1128/MCB.23.16.5692-5705.2003. ISSN 0270-7306. PMC 166352. PMID 12897141. 
  12. ^ Imataka, H; Gradi A; Sonenberg N (December 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. (ENGLAND) 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. ISSN 0261-4189. PMC 1171091. PMID 9857202. 

Further reading[edit]