Eusebio could only manage 36 appearances in his last two seasons combined, this prompting a moved to Celta de Vigo in 1995 where he posted two more solid campaigns. He retired in 2002 at the age of 38 with first side Valladolid, having played 543 La Liga games (the only division he competed in after being promoted to his first club's first team), second-best in the competition only behind goalkeeperAndoni Zubizarreta.
Upon retiring Sacristán opened a football school in Valladolid, for 6-to-12-year-old children. He also obtained his coaching degree and, from 2003 to 2008, was part of Frank Rijkaard's staff at Barcelona.
In March 2009 Eusebio was named head coach of another former side, Celta, as the Galiciansstruggled in the second division. In the following season more of the same (although the club eventually easily retained its division status, it struggled until the last month of competition), and he was dismissed in June 2010.