He first entered the leftist student movement in 1903 during his studies at the Moscow University and soon joined the Menshevik wing of the Russian Social Democratic Labour Party. He was involved in the 1905 revolution in Georgia and was elected a member to the Third State Duma for the Kutais Governorate from 1907 to 1912. During the February Revolution in 1917, Gegechkori became commissar for the Russian Provisional Government in western Georgia. From November 28, 1917 to March 26, 1918, he chaired the Transcaucasian Commissariat and served as minister of labor before leading the Transcaucasian Sejm and becoming its minister of war. After the establishment of the Democratic Republic of Georgia in May 1918, he became its Minister of Foreign Affairs. In 1921, he briefly served as a Minister of Justice. After the Red Army invasion of Georgia, Gegechkori left for France in March 1921. From 1953 until his death, he headed the Georgian government in exile.
- Mikaberidze, Alexander (ed., 2007), Gegechkori, Evgeni. Dictionary of Georgian National Biography. Retrieved on April 29, 2007.
- Jones, Stephen F. (2005), Socialism in Georgian Colors: The European Road to Social Democracy, 1883-1917. Harvard University Press, ISBN 0-674-01902-4.
- The history of the Ministry of Justice of Georgia. Ministry of Justice of Georgia. Accessed on November 20, 2007.