Evodiamine
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| Systematic (IUPAC) name | |
| 21-methyl-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15,17,19-heptaen-14-one | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 518-17-2  |
| ATC code | None |
| PubChem | CID 151289 |
| ChemSpider | 133343 |
| ChEMBL | CHEMBL486598  |
| Chemical data | |
| Formula | C19H17N3O |
| Mol. mass | 303.36 g/mol |
| SMILES | eMolecules & PubChem |
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Evodiamine is a chemical extracted from the Tetradium family of plants, which has been shown to reduce fat uptake in mouse studies. It is suspected that its mechanism of action is similar to that of capsaicin.[1] As such, it has been included in some dietary supplements. Neither its fat-burning effects in humans nor any potential side effects have been empirically established.
Evodiamine acts primarily as a thermogenic and stimulant.[2]
[edit] References
- ^ Kobayashi, Y. et al. (2001): Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. In: Planta Med. 67(7); 628–33; PMID 11582540
- ^ Wang, T. et al. (2008): Evodiamine improves diet-induced obesity in an uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase/mitogen-activated protein kinase signaling. In: Endocrinology 149(1); 358–66; PMID 17884939
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