It rises in the town of Chester, 12 miles (19 km) southeast of Manchester. It follows a winding course east and northeast to Exeter, where it becomes the Squamscott River, a tidal river leading north to Great Bay. There are falls and small dams at Exeter and several other villages along the river. Its drainage basin encompasses an area of 126 square miles (330 km2). The upper 33.3 miles (53.6 km) of the river, from its headwaters to its confluence with Great Brook in Exeter, were designated into the NH Rivers Management and Protection Program in August 1995.
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