Exonuclease VII

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Exonuclease VII, large subunit
Identifiers
Symbol Exonuc_VII_L
Pfam PF02601
InterPro IPR020579
Exonuclease VII small subunit
PDB 1vp7 EBI.jpg
crystal structure of exodeoxyribonuclease vii small subunit (np_881400.1) from bordetella pertussis at 2.40 a resolution
Identifiers
Symbol Exonuc_VII_S
Pfam PF02609
InterPro IPR003761

In molecular biology, exonuclease VII (EC 3.1.11.6, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, Exodeoxyribonuclease VII) is a bacterial exonuclease enzyme.[1][2] It is composed of two nonidentical subunits; one large subunit and 4 small ones.[3] Exonuclease VII catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.

References[edit]

  1. ^ Chase, J.W. and Richardson, C.C. (1974). "Ribonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4545–4552. PMID 4602029. 
  2. ^ Chase, J.W. and Richardson, C.C. (1974). "Exonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4553–4561. PMID 4602030. 
  3. ^ Vales LD, Rabin BA, Chase JW (August 1982). "Subunit structure of Escherichia coli exonuclease VII". J. Biol. Chem. 257 (15): 8799–805. PMID 6284744. 

This article incorporates text from the public domain Pfam and InterPro IPR020579

This article incorporates text from the public domain Pfam and InterPro IPR003761